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Details

Stereochemistry ACHIRAL
Molecular Formula C7H12N2O2
Molecular Weight 156.1824
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ECTYLUREA

SMILES

CC\C(=C\C)C(=O)NC(N)=O

InChI

InChIKey=QCUPYFTWJOZAOB-HYXAFXHYSA-N
InChI=1S/C7H12N2O2/c1-3-5(4-2)6(10)9-7(8)11/h3H,4H2,1-2H3,(H3,8,9,10,11)/b5-3-

HIDE SMILES / InChI

Description

ECTYLUREA is used for the symptomatic treatment of tension and anxiety. It has no convulsant, analgesic or antispasmodic activity in animals. ECTYLUREA in therapeutic amounts has no effect on the autonomic nervous system. It also has no hypnotic effect unless given in a large dose.

CNS Activity

Approval Year

1956
94
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Nostyn

Approved Use

Sedative and tranquilizer
Doses

Doses

DosePopulationAdverse events​
300 mg 3 times / day multiple, oral
Dose: 300 mg, 3 times / day
Route: oral
Route: multiple
Dose: 300 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13578110
unhealthy, 35 years
n = 1
Health Status: unhealthy
Condition: mild anxiety
Age Group: 35 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/13578110
Disc. AE: Hepatitis...
AEs leading to
discontinuation/dose reduction:
Hepatitis (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/13578110
AEs

AEs

AESignificanceDosePopulation
Hepatitis 1 patient
Disc. AE
300 mg 3 times / day multiple, oral
Dose: 300 mg, 3 times / day
Route: oral
Route: multiple
Dose: 300 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/13578110
unhealthy, 35 years
n = 1
Health Status: unhealthy
Condition: mild anxiety
Age Group: 35 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/13578110
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1NYY3N
AHH Chemical co.,ltd
MT-49336
http://www.ahhchemical.com/product/MT-49336.html
Ambinter
Amb24099380
http://www.ambinter.com/reference/24099380
Chemieliva Pharmaceutical Co., Ltd
PBCM0000306
Enamine
BBV-38278612
Enamine
BBV-77637189
LGC Standards
LGCFOR1380.00
https://www.lgcstandards.com/US/en/p/LGCFOR1380.00
NCI Plated 2007
11776
NCI Plated 2007
163913
NCI Plated 2007
169502
Norris Pharm
NSZB-A220618
Smolecule
S526865
http://www.smolecule.com/products/s526865
THE BioTek
bt-267042
https://www.thebiotek.com/product/inhibitors/bt-267042
Tetrahedron
TS10685
Tetrahedron
TS41608
TimTec
ST50545702
ZINC
ZINC000000001340
http://zinc15.docking.org/substances/ZINC000000001340
eMolecules
1014251
eMolecules
96282500
eNovation Chemicals
D670157
https://www.enovationchem.com/ProductDetails.asp?ProductID=D670157
mcule
MCULE-4660531154
PubMed

PubMed

TitleDatePubMed
A new compound for the symptomatic treatment of tension and anxiety: 2-ethylcrotonylurea (nostyn).
1956 Oct
A clinical evaluation of ectylurea (nostyn).
1958 Feb 15
Jaundice due to ectylurea.
1958 Sep 18
Drugs which stimulate affective behaviour. 3. Comparison of the effect of picrotoxin, pentylenetetrazol, bemigride, pipradrol, ectylurea, vanillic acid diethylamide and deanol.
1960 Jul
Name Type Language
ECTYLUREA
INN   MI   WHO-DD  
INN  
Official Name English
Ectylurea [WHO-DD]
Common Name English
ECTYLCARBAMIDE
Common Name English
CRONIL
Brand Name English
NEUROPROCIN
Brand Name English
(Z)-N-(AMINOCARBONYL)-2-ETHYL-2-BUTENAMIDE
Systematic Name English
EKTYL
Brand Name English
NOSTAL
Brand Name English
(Z)-(.ALPHA.-ETHYLCROTONYL)CARBAMIDE
Common Name English
NOSTYN
Brand Name English
2-BUTENAMIDE, N-(AMINOCARBONYL)-2-ETHYL-, (Z)-
Systematic Name English
ASTYN
Brand Name English
UREA, (2-ETHYLCROTONOYL)-, CIS-
Common Name English
2-BUTENAMIDE, N-(AMINOCARBONYL)-2-ETHYL-
Systematic Name English
ectylurea [INN]
Common Name English
CIS-(2-ETHYLCROTONYL)UREA
Common Name English
PACETYN
Brand Name English
ECTYLUREA [MI]
Common Name English
LEVANIL
Brand Name English
NSC-163913
Code English
(2-ETHYLCROTONYL)UREA
Systematic Name English
NSC-169502
Code English
Classification Tree Code System Code
NCI_THESAURUS C29756
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
Code System Code Type Description
MERCK INDEX
m714
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C76939
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
CAS
5982-97-8
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
NON-SPECIFIC STEREOCHEMISTRY
FDA UNII
1U73ZZU4JK
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
SMS_ID
100000080489
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
CAS
95-04-5
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
PUBCHEM
5895404
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
ECHA (EC/EINECS)
227-794-3
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
NON-SPECIFIC STEREOCHEMISTRY
INN
237
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
EPA CompTox
DTXSID0049024
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
NSC
169502
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
ChEMBL
CHEMBL1908316
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
ECHA (EC/EINECS)
202-386-8
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
DRUG CENTRAL
984
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
EVMPD
SUB06452MIG
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
NSC
163913
Created by admin on Fri Dec 15 15:22:00 UTC 2023 , Edited by admin on Fri Dec 15 15:22:00 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of ECTYLUREA
NIH
NCATS
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