ECTYLUREA

US Previously Marketed

First approved in 1956

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H12N2O2
Molecular Weight	156.1824
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC\C(=C\C)C(=O)NC(N)=O

InChI

InChIKey=QCUPYFTWJOZAOB-HYXAFXHYSA-N

InChI=1S/C7H12N2O2/c1-3-5(4-2)6(10)9-7(8)11/h3H,4H2,1-2H3,(H3,8,9,10,11)/b5-3-

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13817064 | https://www.ncbi.nlm.nih.gov/pubmed/13363376

ECTYLUREA is used for the symptomatic treatment of tension and anxiety. It has no convulsant, analgesic or antispasmodic activity in animals. ECTYLUREA in therapeutic amounts has no effect on the autonomic nervous system. It also has no hypnotic effect unless given in a large dose.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: https://books.google.ru/books?id=v2vwCAAAQBAJ&pg=PA47&lpg=PA47&dq=A+clinical+evaluation+of+ectylurea+(nostyn).&source=bl&ots=ZFQld-ft1y&sig=JU7CYBjB6BFyPBYx0WrP21NsehQ&hl=en&sa=X&ved=0ahUKEwj6ucPNo6HbAhUCfywKHYxmCe0Q6AEIODAE#v=onepage&q&f=false	Primary		Approved 8429	Nostyn Approved Use Sedative and tranquilizer

Doses

Dose	Population	Adverse events
300 mg 3 times / day multiple, oral Dose: 300 mg, 3 times / day Route: oral Route: multiple Dose: 300 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13578110	unhealthy, 35 years n = 1 Health Status: unhealthy Condition: mild anxiety Age Group: 35 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/13578110	Disc. AE: Hepatitis... AEs leading to discontinuation/dose reduction: Hepatitis (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13578110

AEs

AE	Significance	Dose	Population
Hepatitis	1 patient Disc. AE	300 mg 3 times / day multiple, oral Dose: 300 mg, 3 times / day Route: oral Route: multiple Dose: 300 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13578110	unhealthy, 35 years n = 1 Health Status: unhealthy Condition: mild anxiety Age Group: 35 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/13578110

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1NYY3N
AHH Chemical co.,ltd	MT-49336	http://www.ahhchemical.com/product/MT-49336.html
Ambinter	Amb24099380	http://www.ambinter.com/reference/24099380
Chemieliva Pharmaceutical Co., Ltd	PBCM0000306
Enamine	BBV-38278612
Enamine	BBV-77637189
LGC Standards	LGCFOR1380.00	https://www.lgcstandards.com/US/en/p/LGCFOR1380.00
NCI Plated 2007	11776
NCI Plated 2007	163913
NCI Plated 2007	169502
Norris Pharm	NSZB-A220618
Smolecule	S526865	http://www.smolecule.com/products/s526865
THE BioTek	bt-267042	https://www.thebiotek.com/product/inhibitors/bt-267042
Tetrahedron	TS10685
Tetrahedron	TS41608
TimTec	ST50545702
ZINC	ZINC000000001340	http://zinc15.docking.org/substances/ZINC000000001340
eMolecules	1014251
eMolecules	96282500
eNovation Chemicals	D670157	https://www.enovationchem.com/ProductDetails.asp?ProductID=D670157
mcule	MCULE-4660531154

PubMed

Title	Date	PubMed
A new compound for the symptomatic treatment of tension and anxiety: 2-ethylcrotonylurea (nostyn).	1956 Oct	13363376
A clinical evaluation of ectylurea (nostyn).	1958 Feb 15	13504510
Jaundice due to ectylurea.	1958 Sep 18	13578110
Drugs which stimulate affective behaviour. 3. Comparison of the effect of picrotoxin, pentylenetetrazol, bemigride, pipradrol, ectylurea, vanillic acid diethylamide and deanol.	1960 Jul	13817064

Name

Type

Language

ECTYLUREA

Official Name

English

Ectylurea [WHO-DD]

Common Name

English

ECTYLCARBAMIDE

Common Name

English

CRONIL

Brand Name

English

NEUROPROCIN

Brand Name

English

(Z)-N-(AMINOCARBONYL)-2-ETHYL-2-BUTENAMIDE

Systematic Name

English

EKTYL

Brand Name

English

NOSTAL

Brand Name

English

(Z)-(.ALPHA.-ETHYLCROTONYL)CARBAMIDE

Common Name

English

NOSTYN

Brand Name

English

2-BUTENAMIDE, N-(AMINOCARBONYL)-2-ETHYL-, (Z)-

Systematic Name

English

ASTYN

Brand Name

English

UREA, (2-ETHYLCROTONOYL)-, CIS-

Common Name

English

2-BUTENAMIDE, N-(AMINOCARBONYL)-2-ETHYL-

Systematic Name

English

ectylurea [INN]

Common Name

English

CIS-(2-ETHYLCROTONYL)UREA

Common Name

English

PACETYN

Brand Name

English

ECTYLUREA [MI]

Common Name

English

LEVANIL

Brand Name

English

NSC-163913

Code

English

(2-ETHYLCROTONYL)UREA

Systematic Name

English

NSC-169502

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29756