NIPECOTIC ACID

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H11NO2
Molecular Weight	129.157
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OC(=O)C1CCCNC1

InChI

InChIKey=XJLSEXAGTJCILF-UHFFFAOYSA-N

InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
GABA transporter 1 8	Inhibitor 8,297	8.0 µM [IC50]
GABA transporter 2 3	Inhibitor 8,297	38.0 µM [IC50]
GABA transporter 3 6	Inhibitor 8,297	106.0 µM [IC50]

PubMed

Show entries

Title	Date	PubMed
Tiagabine in clinical practice.	2001	11520322
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.	2001 Nov	11597457
Functional significance of nitric oxide in ionomycin-evoked [3H]GABA release from mouse cerebral cortical neurons.	2002 Apr	12067225
Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.	2002 Apr 15	11956334
Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections.	2002 Aug	12127027

Showing 1 to 5 of 27 entries

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Patents

Show entries

Name

Type

Language

NIPECOTIC ACID

Systematic Name

English

NIPECOTIC ACID, (±)-ISOMER

Common Name

English

(±)-NIPECOTIC ACID

Systematic Name

English

3-CARBOXYPIPERIDINE

Systematic Name

English

PIPERIDINE-3-CARBOXYLIC ACID

Systematic Name

English

Showing 1 to 5 of 8 entries

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Show entries

Code System

Code

Type

Description

FDA UNII

1U1QTN40SY

PRIMARY

PUBCHEM

4498

PRIMARY

CHEBI

116931

PRIMARY

WIKIPEDIA

Nipecotic acid

PRIMARY

CAS

498-95-3

PRIMARY

Showing 1 to 5 of 8 entries

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SALT/SOLVATE (PARENT)


					4FFB4R29DS

NIPECOTIC ACID, SODIUM SALT

SUBSTANCE RECORD


					1U1QTN40SY

NIPECOTIC ACID