Details
Stereochemistry | MIXED |
Molecular Formula | C26H29NO3 |
Molecular Weight | 403.5134 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(CCC1C2=CC=CC=C2OCC3=C1C=CC=C3)CC(O)COC4=CC=CC=C4
InChI
InChIKey=SZQLTQPHXXXMNC-UHFFFAOYSA-N
InChI=1S/C26H29NO3/c1-27(17-21(28)19-29-22-10-3-2-4-11-22)16-15-24-23-12-6-5-9-20(23)18-30-26-14-8-7-13-25(24)26/h2-14,21,24,28H,15-19H2,1H3
Doxaminol is a recently developed beta-sympathomimetic agent, which has shown promising positive inotropic activity in experimental animal models. It is a dibenzoxepine derivative. In normal volunteers, doxaminol exhibits effects on noninvasive cardiological indices similar to those observed after cardiac glycosides. After single-dose application of doxaminol in cases of congestive heart failure, cardiac output and stroke volume increased, heart rate increased slightly, pulmonary and systemic arterial pressure remained constant, and peripheral vascular resistance decreased. No arrhythmias appeared, but one patient suffered an attack of angina.
Approval Year
PubMed
Title | Date | PubMed |
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[Positive inotropic effects of doxaminol in congestive heart failure]. | 1983 Jan |
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Increase in the cardiotonic action and in the therapeutic margin of digoxin by the adrenergic beta-stimulant doxaminol in cats. | 1985 |
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A postulated mechanism of beta-sympathomimetic induction of rib and limb anomalies in rat fetuses. | 1985 Jun |
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Biotransformation of the partial beta-agonist doxaminol in dog. | 1990 Feb |
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Pharmacokinetics of the partial beta-agonist doxaminol in dog. | 1990 Jan |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7066168
Single dose - 20 mg
Route of Administration:
Oral
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NCI_THESAURUS |
C48149
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ACTIVE MOIETY