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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H23N5O2.ClH
Molecular Weight 365.858
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SUNEPITRON HYDROCHLORIDE

SMILES

Cl.[H][C@@]12CC[C@H](CN3C(=O)CCC3=O)CN1CCN(C2)C4=NC=CC=N4

InChI

InChIKey=HWGPYTRJVVMHGT-IODNYQNNSA-N
InChI=1S/C17H23N5O2.ClH/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17;/h1,6-7,13-14H,2-5,8-12H2;1H/t13-,14-;/m0./s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including: http://en.pharmacodia.com/web/drug/1_8718.html

Sunepitron (CP-93,393) is an anxiolytic drug with highly selective serotonin 5-hydroxytryptamine 1A autoreceptor agonist, alpha2-adrenergic antagonist, and dopamine D2 agonist properties. Sunepitron hydrochloride had been in Phase III clinical trials by Pfizer for the treatment of anxiety disorder and depression. However, this research has been discontinued.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.02 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
10.92 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2.36 ng × h/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
87.33 ng × h/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.9 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
4.1 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SUNEPITRON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
5 mg single, oral
Dose: 5 mg
Route: oral
Route: single
Dose: 5 mg
Sources:
healthy
n = 6
Health Status: healthy
Sex: M
Food Status: UNKNOWN
Population Size: 6
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
major
PubMed

PubMed

TitleDatePubMed
Metabolism and excretion of a new antianxiety drug candidate, CP-93,393, in cynomolgus monkeys: identification of the novel pyrimidine ring cleaved metabolites.
1997 Dec
Metabolism and excretion of a new anxiolytic drug candidate, CP-93, 393, in healthy male volunteers.
1998 May
Assay and purity evaluation of sunepitron hydrochloride by reversed-phase liquid chromatography using a reference standard composite.
1998 Nov
Psychopharmacology of depression in the next millennium.
1999 Jul
Patents

Sample Use Guides

The excretion, biotransformation, and pharmacokinetics of Sunepitron (CP-93,393) were investigated in six healthy male volunteers after oral administration of a 5-mg dose of [14C]CP-93,393.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
SUNEPITRON HYDROCHLORIDE
USAN  
USAN  
Official Name English
N-((7S,9AS)-OCTAHYDRO-2-(2-PYRIMIDINYL)-2H-PYRIDO(1,2-A)PYRAZIN-7-YL)METHYL)SUCCINIMIDE MONOHYDROCHLORIDE
Common Name English
CP-93393-1
Code English
SUNEPITRON HYDROCHLORIDE [USAN]
Common Name English
CP-93,393-1
Code English
Classification Tree Code System Code
NCI_THESAURUS C47794
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
NCI_THESAURUS C29713
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2111058
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY
PUBCHEM
6918176
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID10869968
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY
FDA UNII
1NYW5HLO1E
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY
NCI_THESAURUS
C152474
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY
CAS
148408-65-5
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY
USAN
FF-80
Created by admin on Fri Dec 15 18:02:32 GMT 2023 , Edited by admin on Fri Dec 15 18:02:32 GMT 2023
PRIMARY