U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Fe.3O
Molecular Weight 159.688
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC OXIDE RED

SMILES

[O--].[O--].[O--].[Fe+3].[Fe+3]

InChI

InChIKey=LIKBJVNGSGBSGK-UHFFFAOYSA-N
InChI=1S/2Fe.3O/q2*+3;3*-2

HIDE SMILES / InChI

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972 Jan
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014 Aug 26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
2016 May 17
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.
2017 Jul
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
FERRIC OXIDE RED
II  
Common Name English
DAI COUNTRY RED STONE
Common Name English
FERRIC OXIDE RED-BROWN
Common Name English
FERRIC OXIDE RED 30 [II]
Common Name English
BLOOD STONE
Common Name English
INS NO.172(II)
Common Name English
STONE RED
Common Name English
ANHYDROUS FERRIC OXIDE
Common Name English
PIGMENT BROWN 7
Common Name English
FERRIC OXIDE (ANHYDROUS) [NF]
Common Name English
CI (1975) NO. 77491
Common Name English
IRON OXIDE RED
Common Name English
IRON(III) OXIDE (E 172)
Common Name English
HAEMATITUM
CHP  
Common Name English
COSMETIC RED OXIDE
Common Name English
RED IRON OXIDE R 1599D
Code English
IRON OXIDES [VANDF]
Common Name English
Hematite [WHO-DD]
Common Name English
RED FERRIC OXIDE
Common Name English
IRON OXIDE, RED
Common Name English
INS-172(II)
Common Name English
CI 77491 [INCI]
Common Name English
IRON OXIDE
Common Name English
RED OCHRE
Common Name English
ANHYDROUS IRON (III) OXIDE
Common Name English
IRON OXIDE (E172)
Common Name English
FERRIC OXIDE RED [GREEN BOOK]
Common Name English
E-172(II)
Common Name English
IRON OXIDES [INCI]
Common Name English
PIGMENT RED 101
Common Name English
IRON OXIDE, SYNTHETIC
Common Name English
FERRIC OXIDE [II]
Common Name English
DAI ZHE HI
Common Name English
INDIAN RED
Common Name English
IRON(III) OXIDE
Common Name English
CALAMINE COMPONENT FERRIC OXIDE RED
Common Name English
CI 77491
INCI  
INCI  
Official Name English
ZHESHI
Common Name English
RUBIGO
Common Name English
PIGMENT BROWN 6
Common Name English
IRON OXIDE REDDISH-BROWN
Common Name English
OCHERUM RUBRUM
Common Name English
JEWELER'S ROUGE
Common Name English
C.I. PIGMENT RED 101
Common Name English
RED IRON OXIDE
Common Name English
COLCOTHAR
Common Name English
FERRIC OXIDE
II   MI   VANDF  
Common Name English
C.I. PIGMENT RED 102
Common Name English
HEMATITE
INCI  
INCI  
Official Name English
FERRIC OXIDE, RED
Common Name English
IRON OXIDE (FE2O3)
Common Name English
E 172 RED
Code English
IRON OXIDE, RED (172(II))
Common Name English
FERRIC OXIDE [MI]
Common Name English
DIIRON TRIOXIDE
Common Name English
HAEMATITUM [CHP]
Common Name English
NATURAL RED OXIDE
Common Name English
FERRIC OXIDE [IARC]
Common Name English
CI PIGMENT RED 101 AND 102
Common Name English
FERRIC OXIDE RED COMPONENT OF CALAMINE
Common Name English
IRON OXIDES
VANDF  
INCI  
Official Name English
C.I. 77491
Common Name English
IRON TRIOXIDE
Common Name English
FERRIC OXIDE,RED [VANDF]
Common Name English
MAPICO RED
Common Name English
HEMATITE [INCI]
Common Name English
FERRIC OXIDE RED 30
II  
Common Name English
FERRIC OXIDE [VANDF]
Common Name English
FERRIC OXIDE RED [II]
Common Name English
Classification Tree Code System Code
WHO-ATC B03AD04
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
CFR 21 CFR 186.1300
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
DSLD 3326 (Number of products:1)
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-172(II)
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
JECFA EVALUATION INS-172(II)
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
WHO-ATC V08CB03
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
EPA PESTICIDE CODE 100172
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
CFR 21 CFR 186.1374
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
NCI_THESAURUS C461
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
Code System Code Type Description
HSDB
452
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
SMS_ID
100000076161
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
RXCUI
1310572
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID0029632
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
PUBCHEM
14833
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
CHEBI
50819
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
WIKIPEDIA
IRON(III) OXIDE
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
MERCK INDEX
m5325
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY Merck Index
CAS
1317-60-8
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
ALTERNATIVE
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
CONCEPT Industrial Aid
CAS
1309-37-1
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
CAS
1332-37-2
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
ALTERNATIVE
ECHA (EC/EINECS)
215-168-2
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
CHEBI
50818
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
DRUG CENTRAL
4443
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-570-8
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
ALTERNATIVE
EVMPD
SUB16058MIG
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
CAS
12002-17-4
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
ALTERNATIVE
DAILYMED
1K09F3G675
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
MERCK INDEX
m5362
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY Merck Index
FDA UNII
1K09F3G675
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
EVMPD
SUB23080
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
DRUG BANK
DB11576
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
CHEBI
50820
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-275-4
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
ALTERNATIVE
NCI_THESAURUS
C75672
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
EVMPD
SUB168473
Created by admin on Fri Dec 15 15:30:35 GMT 2023 , Edited by admin on Fri Dec 15 15:30:35 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of FERRIC CATION
SUBSTANCE RECORD
Structure of FERRIC OXIDE RED
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966