Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C35H58O12 |
Molecular Weight | 670.8278 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 12 / 12 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1([C@H](O)CCCCC)[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O
InChI
InChIKey=AGJUUQSLGVCRQA-SWOUQTJZSA-N
InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+/t23-,24+,25-,26+,27-,28+,29-,30+,31-,32-,33-,34-/m1/s1
DescriptionSources: http://www.lesgaga.com/pipeline.htmlCurator's Comment: Description was created based on several sources, including
http://print.ispub.com/api/0/ispub-article/5140 and http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=193796
Sources: http://www.lesgaga.com/pipeline.html
Curator's Comment: Description was created based on several sources, including
http://print.ispub.com/api/0/ispub-article/5140 and http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=193796
Pentamycin, also called fungichromin, is a macrolide antibiotic. Pentamycin is a polyene antifungal antibiotic obtained from Streptomyces pentaticus. Pentamycin is a unique treatment for all types of infectious vaginitis, a common condition affecting up to 10% of all women each year whose treatment generates more than 100 million prescriptions per year across Europe and North America. Pentamycin has been shown to be effective against all pathogens which cause infectious vaginitis without negative effect on critical components of the vagina ’s natural flora. Pentamycin is not absorbed into the bloodstream and is well tolerated. In addition, its spectrum includes activity against pathogens resistant to current standard treatment. Pentamycin under the brand name FemiFec is approved in Switzerland for the treatment of vaginitis. FemiFect is the first broad-spectrum antibiotic approved to treat all three of the most common infections known to cause vaginitis: bacteria, fungi and protozoa. Due to the specific molecular structure of pentamycin, FemiFect has several unique properties that clearly differentiate it from existing products: Broad spectrum: Effective against all major pathogens involved in vaginitis; Safety profile: No systemic absorption due to a large molecule size; Resistance: No development of resistance reported to date.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Trichomonas vaginalis growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/25703311 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sources: http://www.lesgaga.com/pipeline.html |
Curative | FemiFect Approved UseFemiFect (pentamycin) is the first broad-spectrum antibiotic approved to treat all three of the most common infections known to cause vaginitis: bacteria, fungi and protozoa. Launch Date2009 |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/20551634
Curator's Comment: vaginal tablet
Intravaginally (3-100 mg) daily for 6 days.
Route of Administration:
Vaginal
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/25703311
Treatment with 15 ug/mL (22 uM) of Pentamycin for 1 h or with ≥1 ug/mL (≥1.5 uM) for 24 h totally eradicated trichomonads
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WHO-ATC |
G01AA11
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WHO-VATC |
QG01AA11
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100000079757
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SUB14796MIG
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3254
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1JB340D58S
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DTXSID4046866
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229-913-4
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5282200
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DB13571
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PENTAMYCIN
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105388
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276732
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C011827
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6834-98-6
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SUBSTANCE RECORD