Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H31N5O3 |
Molecular Weight | 401.5025 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(C=CC=C1)N2CCN(CCCNC3=C(C)C(=O)N(C)C(=O)N3C)CC2
InChI
InChIKey=HIHZDNKKIUQQSC-UHFFFAOYSA-N
InChI=1S/C21H31N5O3/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4/h5-6,8-9,22H,7,10-15H2,1-4H3
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL229 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9490024 |
9.2 null [pKi] | ||
Target ID: CHEMBL232 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9249248 |
7.7 null [pKi] | ||
Target ID: CHEMBL223 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9249248 |
8.0 null [pKi] |
PubMed
Title | Date | PubMed |
---|---|---|
Differential cardiovascular effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), flesinoxan, 5-methyl-urapidil and MDL 75,608A in conscious spontaneously hypertensive rats. | 1993 |
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The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. | 1994 Apr |
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Effect of alpha 1 adrenoceptor antagonists on prostatic pressure and blood pressure in the anesthetized dog. | 1994 Jul |
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Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype. | 1996 Jul |
|
Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats. | 1996 Jun 10 |
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Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification. | 1997 Jul |
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Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes. | 1997 Sep 15 |
|
Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms. | 1998 Jan 30 |
|
Characterization of alpha1-adrenoceptor subtypes mediating noradrenaline-induced contraction of rat epididymal vas deferens in calcium-free medium. | 1999 |
|
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists. | 2001 Jul 6 |
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Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. | 2001 Jun |
|
Use of antisense oligonucleotides to verify the role of the alpha(1A)-adrenergic receptor in the contractility of the rat uterus post partum. | 2001 May |
|
Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. | 2004 Oct |
Patents
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Common Name | English | ||
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Systematic Name | English |
Code System | Code | Type | Description | ||
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34661-85-3
Created by
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5640
Created by
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DTXSID60956150
Created by
admin on Fri Dec 15 18:00:29 GMT 2023 , Edited by admin on Fri Dec 15 18:00:29 GMT 2023
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1HLS600135
Created by
admin on Fri Dec 15 18:00:29 GMT 2023 , Edited by admin on Fri Dec 15 18:00:29 GMT 2023
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C057446
Created by
admin on Fri Dec 15 18:00:29 GMT 2023 , Edited by admin on Fri Dec 15 18:00:29 GMT 2023
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SUBSTANCE RECORD