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Details

Stereochemistry ABSOLUTE
Molecular Formula C16H13ClN6
Molecular Weight 324.768
Optical Activity ( + )
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VOROZOLE

SMILES

CN1N=NC2=C1C=C(C=C2)[C@@H](N3C=NC=N3)C4=CC=C(Cl)C=C4

InChI

InChIKey=XLMPPFTZALNBFS-INIZCTEOSA-N
InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3/t16-/m0/s1

HIDE SMILES / InChI

Description

Vorozole is a specific, non-steroidal inhibitor of aromatase enzyme that catalyzes the last step in estrogen biosynthesis. Vorozole interferes with the aromatase heme. The drug can be useful for postmenopausal patients with advanced breast cancer.

Approval Year

Unknown
149,124

Targets

Primary TargetPharmacologyConditionPotency
Aromatase
8
Inhibitor
8,504
 3.0 nM [IC50]

PubMed

Sample Use Guides

In Vivo Use Guide
Randomization was to 12 weeks of 2.5 mg of vorozole per day orally
Route of Administration: Oral
ACTIVE MOIETY
Structure of VOROZOLE
NIH
NCATS
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