U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H16FN7
Molecular Weight 385.397
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMG-319

SMILES

C[C@H](NC1=C2N=CNC2=NC=N1)C3=C(N=C4C=C(F)C=CC4=C3)C5=CC=CC=N5

InChI

InChIKey=KWRYMZHCQIOOEB-LBPRGKRZSA-N
InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1

HIDE SMILES / InChI

Description

AMG-319 is an oral, small molecule inhibitor of PI3Kdelta which is now being tested in phase II for the treatment of head and neck squamous cell carcinoma and in phase I for lymphoid malignancy.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
2015 Jan 8
Patents

Sample Use Guides

In Vivo Use Guide
25, 50, 100, 200, 300 and 400 mg of AMG-319 were administered by mouth once daily.
Route of Administration: Oral
Name Type Language
AMG-319
Common Name English
N-((1S)-1-(7-FLUORO-2-(2-PYRIDYL)QUINOLINE-3-YL)ETHYL)-9H-PURINE-6-AMINE
Systematic Name English
3-QUINOLINEMETHANAMINE, 7-FLUORO-.ALPHA.-METHYL-N-9H-PURIN-6-YL-2-(2-PYRIDINYL)-, (.ALPHA.S)-
Systematic Name English
J3.391.906I
Code English
AMG319
Code English
Code System Code Type Description
ChEMBL
CHEMBL3545048
Created by admin on Tue Oct 22 17:26:42 UTC 2019 , Edited by admin on Tue Oct 22 17:26:42 UTC 2019
PRIMARY
CAS
1608125-21-8
Created by admin on Tue Oct 22 17:26:42 UTC 2019 , Edited by admin on Tue Oct 22 17:26:42 UTC 2019
PRIMARY
PUBCHEM
68947304
Created by admin on Tue Oct 22 17:26:42 UTC 2019 , Edited by admin on Tue Oct 22 17:26:42 UTC 2019
PRIMARY