Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H18N2O5 |
| Molecular Weight | 258.271 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(CC(=O)NO)C(=O)[C@@H]1CCCC[C@@H]1C(O)=O
InChI
InChIKey=QKIVRALZQSUWHH-SFYZADRCSA-N
InChI=1S/C11H18N2O5/c1-13(6-9(14)12-18)10(15)7-4-2-3-5-8(7)11(16)17/h7-8,18H,2-6H2,1H3,(H,12,14)(H,16,17)/t7-,8+/m1/s1
Idrapril is an inhibitor of the angiotensin-converting enzyme the last is responsible for recurrent myocardial infarction in patients with left ventricular dysfunction. Idrapril participated in phase II clinical trials in essential hypertensive patients, where was shown that the drug was well tolerated. In addition, it was involved in preclinical studies as a potential drug to treat heart failure and postmyocardial infarction. However, the development of the drug was discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Alteration of cytochrome P-450 isozymes by captopril and idrapril in hepatic and renal microsomes of normotensive and spontaneously hypertensive rats. | 1997-07 |
|
| Angiotensin-converting enzyme inhibition by hydroxamic zinc-binding idrapril in humans. | 1994-08 |
|
| Oral pharmacokinetics and pharmacodynamics of idrapril calcium, the prototype of a new class of angiotensin converting enzyme inhibitors, in humans. | 1993-12 |
|
| Pharmacokinetics and pharmacodynamics of idrapril in rats, dogs, and humans. | 1993-09-01 |
|
| Pharmacology of idrapril: a new class of angiotensin converting enzyme inhibitors. | 1992-07 |
Sample Use Guides
in 8 healthy men: Increasing doses of 1, 5, and 25 mg idrapril as well as placebo or 5 mg captopril were administered intravenously (i.v.) at 1-week intervals.
oral: healthy volunteers after multiple dosing for 5 days at the doses of 100, 200 and 400 mg twice daily.
Route of Administration:
Other
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C247
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ACTIVE MOIETY
