ALPIROPRIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H26N4O4S
Molecular Weight	382.478
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNS(=O)(=O)C1=CC(C(=O)NCC2CCCN2CC=C)=C(OC)C=C1N

InChI

InChIKey=QRQMZZNDJGHPHZ-UHFFFAOYSA-N

InChI=1S/C17H26N4O4S/c1-4-7-21-8-5-6-12(21)11-20-17(22)13-9-16(26(23,24)19-2)14(18)10-15(13)25-3/h4,9-10,12,19H,1,5-8,11,18H2,2-3H3,(H,20,22)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1672147 | https://drugster.org/antimigraine-drugs/alpiropride | https://eurekamag.com/research/006/949/006949219.php

Alpiropride (RIV-2093) is a dopamine D2-receptor antagonist structurally similar to sulpiride. Alpiropride has been given orally for the treatment and prophylaxis of migraine.

Approval Year

PubMed

Title	Date	PubMed
Liquid chromatographic analysis of alizapride and metoclopramide in human plasma and urine using solid-phase extraction.	1987 Aug 7	3667781
Increased grooming behaviour is induced by apomorphine in mice treated with discriminant benzamide derivatives.	1988 Oct 26	2905270
Dopaminergic regulation of enkephalin release.	1991 Apr	1672147
Inhibitory influence of the mesocortical dopaminergic neurons on their target cells: electrophysiological and pharmacological characterization.	1991 Aug	1865369

Sample Use Guides

In Vivo Use Guide

LD50 in male mice (mg/kg): 44 i.v.; 184 i.p.; 204 s.c.; 3600 orally

Route of Administration: Other

Name

Type

Language

ALPIROPRIDE

Official Name

English

RIV-2093

Code

English

RIVISTEL

Brand Name

English

(±)-N-((1-ALLYL-2-PYRROLIDINYL)METHYL)-4-AMINO-5-(METHYLSULFAMOYL)-O-ANISAMIDE

Common Name

English

4-AMINO-2-METHOXY-5-((METHYLAMINO)SULFONYL)-N-((1-(2-PROPEN-1-YL)-2-PYRROLIDINYL)METHYL)BENZAMIDE

Systematic Name

English

ALPIROPRIDE [MART.]

Common Name

English

alpiropride [INN]

Common Name

English

ALPIROPRIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883