U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CO3.2Al.6Mg.9O.12H2O
Molecular Weight 619.9804
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of HYDROTALCITE

SMILES

C(=O)([O-])[O-].[Al+3].[Al+3].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O.O.O.O.O.O.O.O.O.O.O.O.[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2]

InChI

InChIKey=BEBILBPAQKONJS-UHFFFAOYSA-L
InChI=1S/CH2O3.2Al.6Mg.12H2O.9O/c2-1(3)4;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h(H2,2,3,4);;;;;;;;;12*1H2;;;;;;;;;/q;2*+3;6*+2;;;;;;;;;;;;;9*-2/p-2

HIDE SMILES / InChI

Description
Curator's Comment:: https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Curator's Comment:: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO

Approved Use

Temporarily relieves minor skin irritations due to: – Poison ivy | – Poison oak – Poison sumac | – Insect bites – Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry
Curative
DOMEBORO

Approved Use

This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.
PubMed

PubMed

TitleDatePubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.
1948 Apr 8
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.
1987 Nov 15
Cardiovascular manifestations of aluminium phosphide intoxication.
1989 Sep
Aluminum fluoride inhibition of glucocorticoid receptor inactivation and transformation.
1990 Apr 10
Plasma renin activity in shock due to aluminium phosphide poisoning.
1990 Jun
Hypermagnesemia following aluminum phosphide poisoning.
1991 Feb
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S.
1994 Nov 25
Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.
1995 Nov
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.
1998 Oct
Effect of aluminum phosphide on blood glucose level.
1999 Feb
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Intravascular hemolysis in aluminium phosphide poisoning.
1999 Sep
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.
2002
Aluminum as a toxicant.
2002 Aug
Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system.
2002 May
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
2003
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.
2003 Nov
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.
2003 Nov 15
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.
2003 Sep
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.
2003 Sep 15
The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.
2004 Feb 13
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].
2004 Nov
Aluminum: new recognition of an old problem.
2005 Dec
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
2005 Nov
Aluminum and Alzheimer's disease, a personal perspective after 25 years.
2006
Some aspects of astroglial functions and aluminum implications for neurodegeneration.
2006 Aug 30
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.
2006 Jan
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.
2006 Nov
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.
2006 Nov
Aluminum and Alzheimer's disease: a new look.
2006 Nov
The role of aluminum and copper on neuroinflammation and Alzheimer's disease.
2006 Nov
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.
2006 Nov
Ototoxic effect of Burow solution applied to the guinea pig middle ear.
2007 Aug
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.
2007 Oct
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.
2007 Oct
Reversible myocardial injury associated with aluminum phosphide poisoning.
2007 Sep
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.
2007 Sep-Oct
Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor.
2008 Jul
Aluminum phosphide fatalities at mild exertion in asymptomatic children: a clue to understand the variations of the autopsy findings.
2009 Aug
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.
2009 May 17
Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat.
2010 Jul
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.
2011 Mar
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.
2012 Nov 23
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.
2013 Apr
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.
2013 Nov
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.
2014 Mar 25
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.
2014 Sep
Molecular basis of carcinogenicity of tungsten alloy particles.
2015 Mar 15
Patents

Sample Use Guides

DOMEBORO® SOOTHING SOAK
Route of Administration: Topical
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Name Type Language
HYDROTALCITE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
HYDROTALCITE [INN]
Common Name English
TALCID
Brand Name English
HYDROTALCITE [WHO-DD]
Common Name English
HYDROTALCITE [MI]
Common Name English
ALTACITE
Brand Name English
NACID
Brand Name English
HYDROTALCITE [MART.]
Common Name English
HI-TI
Brand Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 633
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
WHO-ATC A02AD04
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
WHO-VATC QA02AD04
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 193
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
Code System Code Type Description
DRUG BANK
DB13322
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
MESH
C010467
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
PUBCHEM
73415812
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
CAS
454465-31-7
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
ALTERNATIVE
MERCK INDEX
M6994
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY Merck Index
CAS
12304-65-3
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
INN
2841
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
RXCUI
27221
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY RxNorm
EVMPD
SUB08071MIG
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
NCI_THESAURUS
C166469
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY
FDA UNII
17432CG1KU
Created by admin on Sat Jun 26 15:50:35 UTC 2021 , Edited by admin on Sat Jun 26 15:50:35 UTC 2021
PRIMARY