U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CO3.2Al.6Mg.9O.12H2O
Molecular Weight 619.9799
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of HYDROTALCITE

SMILES

O.O.O.O.O.O.O.O.O.O.O.O.[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Mg++].[Mg++].[Mg++].[Mg++].[Mg++].[Mg++].[Al+3].[Al+3].[O-]C([O-])=O

InChI

InChIKey=BEBILBPAQKONJS-UHFFFAOYSA-L
InChI=1S/CH2O3.2Al.6Mg.12H2O.9O/c2-1(3)4;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h(H2,2,3,4);;;;;;;;;12*1H2;;;;;;;;;/q;2*+3;6*+2;;;;;;;;;;;;;9*-2/p-2

HIDE SMILES / InChI

Description

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO
Primary
DOMEBORO
PubMed

PubMed

TitleDatePubMed
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.
2006 Nov
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.
2007 Oct
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.
2007 Oct
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.
2007 Sep-Oct
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.
2013 Nov
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.
2014 Mar 25
Molecular basis of carcinogenicity of tungsten alloy particles.
2015 Mar 15
Patents

Sample Use Guides

In Vivo Use Guide
DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use
Route of Administration: Topical
In Vitro Use Guide
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Name Type Language
HYDROTALCITE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
HYDROTALCITE [INN]
Common Name English
TALCID
Brand Name English
HYDROTALCITE [WHO-DD]
Common Name English
HYDROTALCITE [MI]
Common Name English
ALTACITE
Brand Name English
NACID
Brand Name English
HYDROTALCITE [MART.]
Common Name English
HI-TI
Brand Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 633
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
WHO-ATC A02AD04
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
WHO-VATC QA02AD04
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
Food Contact Sustance Notif, (FCN No.) FCN NO. 193
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
Code System Code Type Description
MESH
C010467
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
PRIMARY
CAS
454465-31-7
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
ALTERNATIVE
MERCK INDEX
M6994
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
PRIMARY Merck Index
CAS
12304-65-3
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
PRIMARY
INN
2841
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
PRIMARY
RXCUI
27221
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
PRIMARY RxNorm
EVMPD
SUB08071MIG
Created by admin on Tue Mar 06 16:56:24 UTC 2018 , Edited by admin on Tue Mar 06 16:56:24 UTC 2018
PRIMARY