FOSENAZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15N2O2P
Molecular Weight	274.2549
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NNC(=O)CP(=O)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=PMHFLBQRALFMRT-UHFFFAOYSA-N

InChI=1S/C14H15N2O2P/c15-16-14(17)11-19(18,12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,11,15H2,(H,16,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7439361 | https://www.rlsnet.ru/mnn_index_id_3060.htm

Fosenazide (phosphabenzide, gidifen, hydiphen or hydrazide of diphenylphosphinylacetic acid) is a tranquilizer. It possesses the central N-cholinolytic, antiadrenergic and antiserotonin effects. Fosenazide is prescribed in Russia only for the treatment of alcohol withdrawal syndrome.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor 35 Target ID: CHEMBL2331074 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7439361 \| https://www.rlsnet.ru/mnn_index_id_3060.htm	Antagonist 2778
acetylcholine secretion, neurotransmission 1 Target ID: GO:0014055 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7439361 \| https://www.rlsnet.ru/mnn_index_id_3060.htm	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Alcohol withdrawal syndrome 1 Sources: https://www.rlsnet.ru/mnn_index_id_3060.htm	Primary		Approved 8429	Fosenazide Approved Use Alcohol Withdrawal Syndrome

PubMed

Title	Date	PubMed
[Pharmacological characteristics of the tranquilizing action of hydiphen].	1980 Jul-Aug	7439361
[Effect of gidifen on behavior and hemodynamic signs of an emotionally stressful reaction].	1980 Mar	7190040
[Pain-alleviating action of gidifen and its combinations with analgesics].	1985 May-Jun	4029376
[Genotoxic effects of metabolic derivatives of the new drug phosphabenzide].	1998 Feb	9589859
Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation.	1998 Nov	18967395

Patents

Sample Use Guides

In Vivo Use Guide

0.18, 0.75, 1.5 g per day

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

FOSENAZIDE

Official Name

English

(DIPHENYLPHOSPHINYL)ACETIC ACID, HYDRAZIDE

Common Name

English

fosenazide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265