FOSENAZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15N2O2P
Molecular Weight	274.2549
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NNC(=O)CP(=O)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=PMHFLBQRALFMRT-UHFFFAOYSA-N

InChI=1S/C14H15N2O2P/c15-16-14(17)11-19(18,12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,11,15H2,(H,16,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7439361 | https://www.rlsnet.ru/mnn_index_id_3060.htm

Fosenazide (phosphabenzide, gidifen, hydiphen or hydrazide of diphenylphosphinylacetic acid) is a tranquilizer. It possesses the central N-cholinolytic, antiadrenergic and antiserotonin effects. Fosenazide is prescribed in Russia only for the treatment of alcohol withdrawal syndrome.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor 35 Target ID: CHEMBL2331074 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7439361 \| https://www.rlsnet.ru/mnn_index_id_3060.htm	Antagonist 2849
acetylcholine secretion, neurotransmission 1 Target ID: GO:0014055 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7439361 \| https://www.rlsnet.ru/mnn_index_id_3060.htm	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Alcohol withdrawal syndrome 1 Sources: https://www.rlsnet.ru/mnn_index_id_3060.htm	Primary		Approved 8583	Fosenazide Approved Use Alcohol Withdrawal Syndrome

PubMed

Title	Date	PubMed
Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation.	1998-11	18967395
[Genotoxic effects of metabolic derivatives of the new drug phosphabenzide].	1998-02	9589859
[Pain-alleviating action of gidifen and its combinations with analgesics].	1985-05-01	4029376
[Pharmacological characteristics of the tranquilizing action of hydiphen].	1980-07-01	7439361
[Effect of gidifen on behavior and hemodynamic signs of an emotionally stressful reaction].	1980-03	7190040

Patents

Sample Use Guides

In Vivo Use Guide

0.18, 0.75, 1.5 g per day

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

(DIPHENYLPHOSPHINYL)ACETIC ACID, HYDRAZIDE

Preferred Name

English

FOSENAZIDE

Official Name

English

fosenazide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265