Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C13H18O7.H2O |
| Molecular Weight | 590.5709 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.OC[C@H]1O[C@@H](OC2=CC=C(CO)C=C2)[C@H](O)[C@@H](O)[C@@H]1O.OC[C@H]3O[C@@H](OC4=CC=C(CO)C=C4)[C@H](O)[C@@H](O)[C@@H]3O
InChI
InChIKey=DKDQHXPYCLUBGO-GPJPVCCNSA-N
InChI=1S/2C13H18O7.H2O/c2*14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13;/h2*1-4,9-18H,5-6H2;1H2/t2*9-,10-,11+,12-,13-;/m11./s1
Gastrodin is the main bioactive component of Gastrodia elata Blume (G. elata). Tian Ma Su Zhu She Ye (contains Gastrodin) It is an extensively used in the clinical practice of traditional Chinese medicine, to treat neurasthenia, neurasthenia syndrome, angioneurotic headache disorder, traumatic brain syndrome, vertigo meniere disease, medicinal with dizziness, vertigo, sudden deafness, vestibular neuronitis, vertebral basilar artery blood supply deficiency, etc. Apart from traditional claims, scientific reports support the antioxidative, anticonvulsive, antiinflammatory, antiepileptic, antiobesity, anxiolytic, and learning and memory improvements in activities of gastrodin
CNS Activity
Curator's Comment: Gastrodin is CNS active in animals. Gastrodin is the main bioactive component of Gastrodia elata Blume (G. elata). It is an extensively used in the clinical practice of traditional Chinese medicine, to treat headache, migraine, dizziness, epilepsy, infantile convulsion, tetany and so on.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2364709 |
1.94 µM [Kd] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
Sample Use Guides
Gastrodin injection (unspecified dosage) is beneficial to old patients with refractory hypertension.
Gastrodin (50 - 100 mg/kg, intraperitoneally) can decrease the volume of cerebral infarction, ameliorate the cerebral injury in the rats of cerebral ischemia-reperfusion.
Route of Administration:
Parenteral
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m5678
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1673O5HJ9J
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72721057
Created by
admin on Sat Dec 16 09:58:08 GMT 2023 , Edited by admin on Sat Dec 16 09:58:08 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD
