RUFLOXACIN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H18FN3O3S.ClH
Molecular Weight	399.867
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1CCN(CC1)C2=C(F)C=C3C(=O)C(=CN4CCSC2=C34)C(O)=O

InChI

InChIKey=LPQOADBMXVRBNX-UHFFFAOYSA-N

InChI=1S/C17H18FN3O3S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H

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Description
Sources: https://www.torrinomedica.it/schede-farmaci/tebraxin_-_tebraxin_150/ | https://www.ncbi.nlm.nih.gov/pubmed/2743869 | https://www.ncbi.nlm.nih.gov/pubmed/1653205

Rufloxacin (MF-934) is a fluoroquinolone antibacterial drug. It acts as a DNA gyrase inhibitor. Rufloxacin shows in vitro antibacterial activity against E. coli, Salmonella, Klebsiella, Proteus and Staphylococcus spp. Lower in vitro activity was observed with Pseudomonas, Serratia, Enterobacter and the streptococci group D. Rufloxacin is indicated for the treatment of lower respiratory tract and urinary tract infections caused by germs sensitive to rufloxacin.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial DNA gyrase 66 Target ID: CHEMBL2311224 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1653205 \| https://www.ncbi.nlm.nih.gov/pubmed/9372430	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Lower respiratory tract infection 2 Sources: https://www.torrinomedica.it/schede-farmaci/tebraxin_-_tebraxin_150/
Urinary tract infections 205 Sources: https://www.torrinomedica.it/schede-farmaci/tebraxin_-_tebraxin_150/https://www.torrinomedica.it/schede-farmaci/tebraxin_-_tebraxin_150/

PubMed

Title	Date	PubMed
The in-vitro activity of two new quinolones: rufloxacin and MF 961.	1992 Jun	1324239
Effects of some quinolones on imipenem-induced seizures in DBA/2 mice.	1994 Mar	8026738
Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques.	2000 Oct	10991859
Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.	2000 Oct	10991858

Sample Use Guides

In Vivo Use Guide

The recommended dosage is 2 Tebraxin tablets (rufloxacin hydrochloride 150 or 200 mg) taken together the first day and one tablet per day in the following days. The duration of the treatment must be adapted to the severity of the case as well as to the clinical and bacteriological course; generally, 5 to 10 days of therapy are sufficient.

Route of Administration: Oral

Name

Type

Language

RUFLOXACIN HYDROCHLORIDE

Common Name

English

RUFLOXACIN HYDROCHLORIDE [MART.]

Common Name

English

MF-934

Code

English

Rufloxacin hydrochloride [WHO-DD]

Common Name

English

RUFLOXACIN HCL

Common Name

English

RUFLOXACIN HYDROCHLORIDE [MI]

Common Name

English

9-FLUORO-10-(N-(4'-METHYL)-PIPERAZINYL)-7-OXO-2,3-DIHYDRO-7H-PYRIDO(1,2,3)(1,4)BENZOTHIAZINE-6-CARBOXYLIC ACID HYDROCHLORIDE

Common Name

English

Code System Code Type Description

CAS

106017-08-7