U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CO2
Molecular Weight 44.0095
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARBON DIOXIDE

SMILES

C(=O)=O

InChI

InChIKey=CURLTUGMZLYLDI-UHFFFAOYSA-N
InChI=1S/CO2/c2-1-3

HIDE SMILES / InChI

Description

Carbon dioxide is a colorless gas occurring naturally in Earth's atmosphere. Carbon dioxide is a primary carbon source for life on Earth. It is produced by all aerobic organisms during metabolism of carbohydrates and lipids. Carbon dioxide is used in food industry as an acidity regulator and for production of carbonated soft drinks and soda water. In medicine, carbon dioxide is commonly used as an insufflation gas for minimally invasive surgery (laparoscopy, endoscopy, and arthroscopy) to enlarge and stabilize body cavities to provide better visibility of the surgical area. A mixture of carbon dioxide and oxygen is used for stimulation of breathing after apnea, in anesthetic procedures to increase the depth of respiration, to facilitate blind intubations in anesthetic practice.

CNS Activity

CNS Penetrant
2344
Curator's Comment:: Carbon dioxide is naturally produced in all tissues.

Originator

Approval Year

1925
1
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8043
Unknown

Approved Use

Carbon dioxide is used to stimulate respiration after a period of apnoea
Primary
Approved
8043
Unknown

Approved Use

Carbon dioxide is used in chronic respiratory obstruction after it has been relieved
Palliative
Approved
8043
Unknown

Approved Use

Carbon dioxide is used to increase cerebral blood flow in arteriosclerotic patients undergoing surgery
PubMed

PubMed

TitleDatePubMed
Crystal structure of NAD-dependent formate dehydrogenase.
1992 Jun 1
Characteristic hydrogen concentrations for various redox processes in batch study.
2001
Effect of sludge-amendment or nutrient addition on the biodegradation of the herbicide isoproturon in soil.
2001 Aug
[Sinusoidal modulated currents alone and in combination with carbon dioxide-hydrogen sulfide baths in juvenile rheumatoid arthritis].
2001 Jul-Aug
Complete nucleotide sequence and organization of the atrazine catabolic plasmid pADP-1 from Pseudomonas sp. strain ADP.
2001 Oct
Primary donor photo-oxidation in photosystem I: a re-evaluation of (P700(+) - P700) Fourier transform infrared difference spectra.
2001 Oct 30
Prevalence of fat embolism following bilateral simultaneous and unilateral total hip arthroplasty performed with or without cement : a prospective, randomized clinical study.
2002 Aug
Salivary cortisol concentrations before and after carbon-dioxide inhalations in children.
2002 Feb 15
HPV in "carcinoma in situ" associated with HIV/AIDS infection: a case report.
2002 Mar-Apr
Pheophytin-protein interactions in photosystem II studied by resonance Raman spectroscopy of modified reaction centers.
2002 Sep 24
Mechanism of action of the diazabicyclononanone-type kappa-agonists.
2003 Apr 10
Applications of laser-based ultrasonics to the characterization of the internal structure of teeth.
2003 Jul
[Effect of premedication on the formation of postoperative pain syndrome].
2003 Jul-Aug
Occult supraglottic lymphatic malformation presenting as obstructive sleep apnea.
2003 Mar
Carbon-dioxide laser-assisted tonsil ablation for adults with chronic tonsillitis: a 6-month follow-up study.
2003 Sep
Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma.
2004 Dec
Treatment of vitiligo by transplantation of cultured pure melanocyte suspension: analysis of 120 cases.
2004 Jul
Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin.
2004 Jul-Aug
Direct determination of carbon dioxide in aqueous solution using mid-infrared quantum cascade lasers.
2004 Jun
Metabolism of 2-mercaptobenzothiazole by Rhodococcus rhodochrous.
2004 Oct
Photochemical preparation of highly functionalized 1-indanones.
2004 Oct 29
Difference between diabetic and nondiabetic smokers in the pituitary response to physical exercise.
2004 Sep
Retention characteristics of porous graphitic carbon in subcritical fluid chromatography with carbon dioxide-methanol mobile phases.
2004 Sep 3
A1 reduction in intact cyanobacterial photosystem I particles studied by time-resolved step-scan Fourier transform infrared difference spectroscopy and isotope labeling.
2005 Feb 15
[Development of gastrotonometry and the future of its use in the monitoring of critically ill patients].
2005 Jan 23
Differentiation of human bone marrow stem cells into cells with a neural phenotype: diverse effects of two specific treatments.
2006 Feb 16
Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice.
2006 Mar
Characterisation of stationary phases in subcritical fluid chromatography with the solvation parameter model. III. Polar stationary phases.
2006 Mar 31
Patents

Patents

03931302
69
03935297
1
03946067
1
03948939
2
03948996
1
03950427
70
03983292
2
03984459
2
03987147
1
03992456
1
04004026
1
04005140
7
04011333
3
04021461
1
04029668
5
04031124
7
04031222
1
04034108
3
04036979
10
04065568
2
04075074
1
04076818
2
04097671
1
04138490
3
04142037
1
04144278
1
04156777
12
04157392
2
04164474
1
04194047
1
04197304
11
04217352
13
04225606
4
04232030
1
04251438
1
04268449
1
04271186
2
04273687
1
04327222
1
04328161
1
04335141
1
04342873
2
04346035
11
04348322
2
04362849
1
04376079
38
04386211
3
04396773
2
04405806
1
04417079
1
04430355
3

Sample Use Guides

In Vivo Use Guide
Carbon dioxide is usually administered through the lungs by inhalation. The major exceptions are when a metered supply is fed into the oxygenator of an extracorporeal circulation of a cardiopulmonary bypass system, and when the gas is used for laparoscopic surgery. As an additive to beverages, carbon dioxide is consumed orally.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
CARBON DIOXIDE
EP   FCC   HSDB   II   INCI   MART.   MI   USP   VANDF   WHO-DD  
INCI  
Official Name English
CARBON DIOXIDE [EP]
Common Name English
CARBON DIOXIDE [GREEN BOOK]
Common Name English
CARBON DIOXIDE [INCI]
Common Name English
INS NO.290
Code English
CARBON DIOXIDE [HSDB]
Common Name English
E-290
Code English
CARBON DIOXIDE [WHO-DD]
Common Name English
DRY ICE (SOLID FORM)
Common Name English
CARBON DIOXIDE [VANDF]
Common Name English
INS-290
Code English
CARBON DIOXIDE [II]
Common Name English
CO2
Common Name English
CARBON DIOXIDE [USP MONOGRAPH]
Common Name English
CARBON DIOXIDE [EP MONOGRAPH]
Common Name English
CARBON DIOXIDE [MI]
Common Name English
CARBON DIOXIDE [FCC]
Common Name English
CARBONIC ACID ANHYDRIDE
Systematic Name English
CARBON DIOXIDE [MART.]
Common Name English
Classification Tree Code System Code
LOINC 16551-4
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LOINC 13538-4
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LOINC 28644-3
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NDF-RT N0000180185
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LOINC 14640-7
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LOINC 51781-3
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LOINC 39465-0
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LOINC 77143-6
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NDF-RT N0000010258
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LOINC 2021-4
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LOINC 2020-6
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LOINC 2018-0
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LOINC 2028-9
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LOINC 32306-3
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JECFA EVALUATION INS-290
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WHO-ATC A06AX02
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LOINC 19212-0
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CFR 21 CFR 862.1160
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LOINC 39466-8
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CODEX ALIMENTARIUS (GSFA) INS-290
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LOINC 28645-0
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LOINC 2022-2
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EPA PESTICIDE CODE 16601
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LOINC 2027-1
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LOINC 13540-0
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LOINC 11557-6
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LOINC 38253-1
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WHO-VATC QA06AX02
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LOINC 34728-6
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LOINC 14040-0
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LOINC 57922-7
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FDA ORPHAN DRUG 465114
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LOINC 57923-5
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LOINC 2026-3
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LOINC 20565-8
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DSLD 3848 (Number of products:1)
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LOINC 53458-6
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LOINC 57921-9
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LOINC 53090-7
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LOINC 2019-8
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LOINC 19223-7
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CFR 21 CFR 184.1240
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LOINC 2023-0
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WHO-VATC QV03AN02
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LOINC 14003-8
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WHO-ATC V03AN02
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Code System Code Type Description
DRUG CENTRAL
4256
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
FDA UNII
142M471B3J
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
DRUG BANK
DB09157
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
JECFA MONOGRAPH
INS-290
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PRIMARY
CAS
124-38-9
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PRIMARY
EPA CompTox
124-38-9
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PRIMARY
MERCK INDEX
M3079
Created by admin on Fri Jun 25 20:53:09 UTC 2021 , Edited by admin on Fri Jun 25 20:53:09 UTC 2021
PRIMARY Merck Index
HSDB
516
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PRIMARY
ChEMBL
CHEMBL1231871
Created by admin on Fri Jun 25 20:53:08 UTC 2021 , Edited by admin on Fri Jun 25 20:53:08 UTC 2021
PRIMARY
WIKIPEDIA
CARBON DIOXIDE
Created by admin on Fri Jun 25 20:53:09 UTC 2021 , Edited by admin on Fri Jun 25 20:53:09 UTC 2021
PRIMARY
PUBCHEM
280
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PRIMARY
MESH
D002245
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PRIMARY
NCI_THESAURUS
C65288
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PRIMARY
RXCUI
2034
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PRIMARY RxNorm
EVMPD
SUB13243MIG
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PRIMARY
ECHA (EC/EINECS)
204-696-9
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PRIMARY
ACTIVE MOIETY
Structure of CARBON DIOXIDE
PARENT (METABOLITE INACTIVE)
Structure of DIMETHYL FUMARATE
PARENT (METABOLITE)
Structure of MONOMETHYL FUMARATE
NIH
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