Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C22H29ClO5 |
Molecular Weight | 408.916 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])[C@H](Cl)CC4=CC(=O)C=C[C@]34C
InChI
InChIKey=FJXOGVLKCZQRDN-PHCHRAKRSA-N
InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1
Alclometasone is synthetic glucocorticoid steroid for topical use. Alclometasone dipropionate cream USP and alclometasone dipropionate ointment USP are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It may be used in pediatric patients 1 year of age or older, although the safety and efficacy of drug use for longer than 3 weeks have not been established. Like other topical corticosteroids, alclometasone dipropionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2034 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | ALCLOMETASONE DIPROPIONATE Approved UseAlclometasone dipropionate cream USP and alclometasone dipropionate ointment USP are low to medium potency corticosteroids indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Alclometasone dipropionate cream USP and alclometasone dipropionate ointment USP may be used in pediatric patients 1 year of age or older, although the safety and efficacy of drug use for longer than 3 weeks have not been established Launch Date2004 |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7708 ng × h/mL/m² EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26063051/ |
4 mg/m² single, topical dose: 4 mg/m² route of administration: Topical experiment type: SINGLE co-administered: |
ALCLOMETASONE unknown | Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN |
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-VATC |
QD07AB10
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
||
|
NDF-RT |
N0000175450
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
||
|
NDF-RT |
N0000175576
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
||
|
NCI_THESAURUS |
C521
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
||
|
WHO-VATC |
QS01BA10
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
||
|
WHO-ATC |
S01BA10
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
||
|
WHO-ATC |
D07AB10
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
4616
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
DTXSID60867277
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
108088
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | RxNorm | ||
|
100000087717
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
67452-97-5
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
SUB05300MIG
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
C65219
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
ALCLOMETASONE
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
5311000
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
136H45TB7B
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
53776
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
136H45TB7B
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
CHEMBL1200989
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
DB00240
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
Alclometasone
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | |||
|
m1483
Created by
admin on Fri Dec 15 16:17:17 GMT 2023 , Edited by admin on Fri Dec 15 16:17:17 GMT 2023
|
PRIMARY | Merck Index |
ACTIVE MOIETY