SAVOXEPIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H26N2O
Molecular Weight	370.4867
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

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Structure Search

SMILES

N#CC1=CC2=C(OC3=C(C=CC=C3)C4=C2CCN(CC5CCCC5)CC4)C=C1

InChI

InChIKey=MUAHMQUPOQGKOQ-UHFFFAOYSA-N

InChI=1S/C25H26N2O/c26-16-19-9-10-25-23(15-19)21-12-14-27(17-18-5-1-2-6-18)13-11-20(21)22-7-3-4-8-24(22)28-25/h3-4,7-10,15,18H,1-2,5-6,11-14,17H2

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2565583 | https://www.ncbi.nlm.nih.gov/pubmed/12111340 | https://adisinsight.springer.com/drugs/800000647

Savoxepine (also known as cipazoxapine), a tetracyclic compound, possesses a potent neuroleptic-like effects. This compound acts via dopamine D(2)-receptor blockade. Savoxepine was studied in phase II clinical trials in Europe for the treatment of patients with psychotic disorders; however, these studied were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Neuroleptic profile of cipazoxapine (Savoxepine), a new tetracyclic dopamine antagonist: clinical validation of the hippocampus versus striatum ratio model of dopamine receptors in animals. A preliminary report.	1987 May	2885867
Savoxepine: striatal dopamine-D2 receptor occupancy in human volunteers measured using positron emission tomography (PET).	1993	8095895
Savoxepine fails to selectively influence glucose metabolism in the rat limbic system.	1994 Mar	7838920
Direct microtitre plate radioimmunoassay of savoxepine in unextracted plasma.	1996 Feb	8926305

Patents

Sample Use Guides

In Vivo Use Guide

In an open pilot-study 18 patients suffering from acute schizophrenic psychoses or paranoid syndromes were treated with savoxepine in an individually adapted dose range from 0.50 to 10 mg per day

Route of Administration: Oral

Name

Type

Language

SAVOXEPIN

Official Name

English

savoxepin [INN]

Common Name

English

3-(CYCLOPENTYLMETHYL)-2,3,4,5-TETRAHYDRO-1H-DIBENZ(2,3:6,7)OXEPINO(4,5-D)AZEPINE-7-CARBONITRILE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883