Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H14FO3P |
Molecular Weight | 184.1457 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)OP(F)(=O)OC(C)C
InChI
InChIKey=MUCZHBLJLSDCSD-UHFFFAOYSA-N
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Granzymes: a family of lymphocyte granule serine proteases. | 2001 |
|
Organophosphorus compounds alter intracellular F-actin content in SH-SY5Y human neuroblastoma cells. | 2001 Dec |
|
Identification, purification, and characterization of a thermally stable lipase from rice bran. A new member of the (phospho) lipase family. | 2001 Dec |
|
Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo. | 2001 Dec |
|
A novel N(alpha)-acetyl alanine aminopeptidase from Allomyces arbuscula. | 2002 Apr |
|
Differential alteration of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). | 2002 Apr |
|
Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils. | 2002 Apr 15 |
|
Analysis of organophosphorus compound adducts of serine proteases by liquid chromatography-tandem mass spectrometry. | 2002 Aug 25 |
|
Involvement of nitric oxide in myotoxicity produced by diisopropylphosphorofluoridate (DFP)-induced muscle hyperactivity. | 2002 Dec |
|
Deacylation of N-arylformamides and N-arylacetamides by formamidase in rat liver. | 2002 Dec |
|
Rapid assessment of organophosphorous/carbamate exposure in the bivalve mollusc Mytilus edulis using combined esterase activities as biomarkers. | 2002 Dec 3 |
|
An antibody that binds to primary specific pocket-associated structure in the active site of bovine thrombin. | 2002 Feb |
|
Ionomycin-induced neutrophil NADPH oxidase activity is selectively inhibited by the serine protease inhibitor diisopropyl fluorophosphate. | 2002 Feb |
|
Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. | 2002 Feb 26 |
|
Purification and some properties of a keratinolytic enzyme from an alkaliphilic Nocardiopsis sp. TOA-1. | 2002 Jan |
|
Effect of meconium on the rate of in vitro subtype conversion of swine pulmonary surfactant. | 2002 Jan |
|
Different expressions of organophosphate-resistant acetylcholinesterases in the bivalve mollusk Scapharca inaequivalvis living in three different habitats. | 2002 Jan |
|
Lecithin: cholesterol acyltransferase is insufficient to prevent oxidative modification of low-density lipoprotein. | 2002 Jan |
|
Purification and characterization of hemolymph juvenile hormone esterase from the cricket, Gryllus assimilis. | 2002 Jan |
|
Juvenile hormone catabolism and oviposition in the codling moth, Cydia pomonella, as functions of age, mating status, and hormone treatment. | 2002 Jan |
|
Protein levels of neurofilament subunits in the hen central nervous system following prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity(1). | 2002 Jan 1 |
|
Reelin is a serine protease of the extracellular matrix. | 2002 Jan 4 |
|
Functional dissociation between proforms and mature forms of proteinase 3, azurocidin, and granzyme B in regulation of granulopoiesis. | 2002 Jul |
|
Characterization and molecular cloning of a glutamyl endopeptidase from Staphylococcus epidermidis. | 2002 Jul |
|
Purification and characterization of an esterase from Acinetobacter lwoffii I6C-1. | 2002 Jun |
|
Pyridostigmine bromide modulates the dermal disposition of [14C]permethrin. | 2002 Jun 15 |
|
Covalent reactivity of phosphonate monophenyl esters with serine proteinases: an overlooked feature of presumed transition state analogs. | 2002 Jun 15 |
|
Nanocrystalline metal oxides as destructive adsorbents for organophosphorus compounds at ambient temperatures. | 2002 Jun 3 |
|
Early differential elevation and persistence of phosphorylated cAMP-response element binding protein (p-CREB) in the central nervous system of hens treated with diisopropyl phosphorofluoridate, an OPIDN-causing compound. | 2002 Mar |
|
EstB from Burkholderia gladioli: a novel esterase with a beta-lactamase fold reveals steric factors to discriminate between esterolytic and beta-lactam cleaving activity. | 2002 Mar |
|
Dipeptidyl peptidase with strict substrate specificity of an anaerobic periodontopathogen Porphyromonas gingivalis. | 2002 Mar 19 |
|
Purification and characterization of a collagenolytic protease from the filefish, Novoden modestrus. | 2002 Mar 31 |
|
[Amylases of the fungus Aspergillus flavipes associated with Fucus evanescens]. | 2002 Mar-Apr |
|
Sulfur mustard-stimulated protease: a target for antivesicant drugs. | 2002 Mar-Apr |
|
Degradation of glyceraldehyde-3-phosphate dehydrogenase induced by acetylleucine chloromethyl ketone in U937 cells. | 2002 May 15 |
|
Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. | 2002 May 15 |
|
Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. | 2002 May 24 |
|
Production of interleukin-1 activity of Kupffer cells from mice treated with the acidic mannan fraction of baker's yeast. | 2002 Nov |
|
Characterization of the receptor-destroying enzyme activity from infectious salmon anaemia virus. | 2002 Nov |
|
The crystal structure of the Epstein-Barr virus protease shows rearrangement of the processed C terminus. | 2002 Nov 15 |
|
A mechanism-based probe for gp120-Hydrolyzing antibodies. | 2002 Nov 4 |
|
Atomic resolution crystal structure of squid ganglion DFPase. | 2002 Oct |
|
Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists. | 2002 Sep |
|
Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1). | 2002 Sep |
|
Gulf War related exposure factors influencing topical absorption of 14C-permethrin. | 2002 Sep 5 |
|
Purification and characterization of PrbA, a new esterase from Enterobacter cloacae hydrolyzing the esters of 4-hydroxybenzoic acid (parabens). | 2003 Apr 11 |
|
Influence of gender on thermoregulation and cholinesterase inhibition in the long-evans rat exposed to diazinon. | 2003 Feb 14 |
|
Structural and enzymatic characterization of physarolisin (formerly physaropepsin) proves that it is a unique serine-carboxyl proteinase. | 2003 Feb 21 |
|
Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. | 2003 Jan 28 |
|
The cholinesterase inhibitor DFP facilitates the expression of paradoxical sleep (PS) propensity in rats subjected to short-term PS deprivation. | 2003 Mar 7 |
Sample Use Guides
Topical, to the conjunctiva, a thin strip (approximately 0.5 cm) of a 0.025% ointment once every three days to three times a day.
Route of Administration:
Topical
Recombinant AChE was quantitated using the extinction coefficient 119, 650 M-1 cm-1 calculated from its amino acid sequence. AChE (34 nM) was assayed using Ellman’s reagent using 160 uM acetylthiocholine and 300 uM 5,50-dithiobis-2-ntirobenzoic acid (DTNB). Thiocholine released by the enzyme reacts with excess DTNB, resulting in the formation of the thionitrobenzoate anion, which absorbs at 412 nm. To assess IC50, the inhibitors were solubilized in isopropanol and used in volumes of less than 5% of the total reaction volume. AChE (34 nM) was incubated for 30 min with each compound at an array of concentrations. The residual activity of the enzyme was assayed using 500 uM acetylthiocholine, a saturating concentration 10-fold higher than the Km of 46 uM for this substrate.
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C47792
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
||
|
EPA PESTICIDE CODE |
356100
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
||
|
WHO-ATC |
S01EB07
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
55-91-4
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
55-91-4
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
CHEMBL1025
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
DIISOPROPYL FLUOROPHOSPHATE
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
6027
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | RxNorm | ||
|
DB00677
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
200-247-6
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
M6492
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | Merck Index | ||
|
D007531
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
SUB14274MIG
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
55-91-4
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
5936
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY | |||
|
C65979
Created by
admin on Tue Oct 22 05:42:18 UTC 2019 , Edited by admin on Tue Oct 22 05:42:18 UTC 2019
|
PRIMARY |
ACTIVE MOIETY