Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H34FN7O4 |
| Molecular Weight | 479.5483 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NC(NNC(=O)[C@H](CC2CCCC2)CN(O)C=O)=C(F)C(=N1)N3CCN4CCOC[C@@H]4C3
InChI
InChIKey=SWHNZGMQMGFQGW-MSOLQXFVSA-N
InChI=1S/C22H34FN7O4/c1-15-24-20(19(23)21(25-15)29-7-6-28-8-9-34-13-18(28)12-29)26-27-22(32)17(11-30(33)14-31)10-16-4-2-3-5-16/h14,16-18,33H,2-13H2,1H3,(H,27,32)(H,24,25,26)/t17-,18+/m1/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Single-dose safety, tolerability, and pharmacokinetics of the antibiotic GSK1322322, a novel peptide deformylase inhibitor. | 2013-05 |
|
| Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322. | 2013-05 |
|
| Antibiotics in development targeting protein synthesis. | 2011-12 |
|
| Determination of disk diffusion and MIC quality control ranges for GSK1322322, a novel peptide deformylase inhibitor. | 2011-11 |
Patents
Sample Use Guides
Lanopepden (GSK1322322) had an MIC90 of 1 μg/ml against M. catarrhalis and 4 μg/ml against H. influenzae, with 88.8% of beta-lactamase-positive strains showing growth inhibition at that concentration. All S. pneumoniae strains were inhibited by ≤ 4 μg/ml of GSK1322322, with an MIC90 of 2 μg/ml. GSK1322322 was very potent against S. pyogenes strains, with an MIC90 of 0.5 μg/ml, irrespective of their macrolide resistance phenotype. It was also active against S. aureus strains regardless of their susceptibility to methicillin, macrolides, or levofloxacin, with an MIC90 of 4 μg/ml in all cases.
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
