Praxadine

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H6N4
Molecular Weight	110.1172
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NC(=N)N1C=CC=N1

InChI

InChIKey=UCQFSGCWHRTMGG-UHFFFAOYSA-N

InChI=1S/C4H6N4/c5-4(6)8-3-1-2-7-8/h1-3H,(H3,5,6)

HIDE SMILES / InChI

Description

Praxadine is the anti-inflammatory and analgesic agent. Praxadine inhibited the activity of purified inducible NOS (iNOS), endothelial NOS (eNOS), and neuronal NOS (nNOS) isoforms to a similar extent.

Approval Year

PubMed

Show entries

Title	Date	PubMed
Inhibition of nitric oxide synthase with pyrazole-1-carboxamidine and related compounds.	1997 Aug 1	9278100
Synthesis, X-ray crystal structures, and phosphate ester cleavage properties of bis(2-pyridylmethyl)amine copper(II) complexes with guanidinium pendant groups.	2008 Oct 6	18754616
Guanidylated hollow fiber membranes based on brominated poly (2,6-dimethyl-1,4-phenylene oxide) (BPPO) for gold sorption from acid solutions.	2012 Nov 30	23046695
Solid-phase guanidinylation of peptidyl amines compatible with standard Fmoc-chemistry: formation of monosubstituted guanidines.	2013	24014439

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Patents

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Name

Type

Language

Praxadine

Official Name

English

1H-Pyrazole-1-carboximidamide

Systematic Name

English

praxadine [INN]

Common Name

English

ZANAMIVIR HYDRATE IMPURITY F [EP IMPURITY]

Common Name

English

Pyrazole-1-carboxamidine

Systematic Name

English

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Classification Tree

Code System

Code

Heterocyclic Compound

NCI_THESAURUS

C29396

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Code System

Code

Type

Description

EVMPD

SUB10005MIG

PRIMARY

INN

3556

PRIMARY

CAS

4023-00-1

PRIMARY

EPA CompTox

DTXSID3048366

PRIMARY

NCI_THESAURUS

C66457

PRIMARY

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ACTIVE MOIETY


					12L58GX4AS

Praxadine

SALT/SOLVATE (PARENT)


					S9X3PXT9NC

Praxadine hydrochloride