FOSFOSAL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7O6P
Molecular Weight	218.1006
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=C(OP(O)(O)=O)C=CC=C1

InChI

InChIKey=FFKUDWZICMJVPA-UHFFFAOYSA-N

InChI=1S/C7H7O6P/c8-7(9)5-3-1-2-4-6(5)13-14(10,11)12/h1-4H,(H,8,9)(H2,10,11,12)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21797253
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3264273 | https://www.ncbi.nlm.nih.gov/pubmed/8008964 | https://www.ncbi.nlm.nih.gov/pubmed/7325717 | https://www.ncbi.nlm.nih.gov/pubmed/7012470 | https://www.ncbi.nlm.nih.gov/pubmed/3163974

Fosfosal (2-phosphonoxybenzoic acid) is a O-phosphorylated derivative of salicylic acid used in analgesic and anti-inflammatory therapy. Fosfosal showed analgesic effect in the acetic acid-induced writhing and in the hot plate tests in mice, and showed antiinflammatory effect in the xylene induced mice ears swelling and in acetic acid induced increased vascular permeability tests in mice. Both the effects had no significant differences between fosfosal and aspirin, but the former had less stomach irritation.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tyrosine-protein kinase SRC 19 Target ID: CHEMBL267 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11965374	Inhibitor 8504		2.0 mM [IC50]
Signal transducer and activator of transcription 5B 1 Target ID: CHEMBL5817 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11965374	Inhibitor 8504		17.4 µM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Musculoskeletal pain 10 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7012470	Primary		Phase II 1147	Unknown Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
276 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3264273	2400 mg 3 times / day steady-state, oral dose: 2400 mg route of administration: Oral experiment type: STEADY-STATE co-administered:		FOSFOSAL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
AK Scientific	5553AL	https://aksci.com/item_detail.php?cat=5553AL
Apollo Scientific	BIC1059	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BIC1059&product_group=%25&search_fieldname=header_search
BLD Pharm	BD4886	http://www.bldpharm.com/search/Search.html?keyword=BD4886
BOC Sciences	6064-83-1	http://www.bocsci.com/description.asp?cas=6064-83-1
BOC Sciences	66032-54-0	http://www.bocsci.com/description.asp?cas=66032-54-0
Chem Scene	CS-0013063	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0013063
ChemBridge	5121808	http://www.hit2lead.com/screening-compounds/5121808
Chemspace	CSC000022359	https://chem-space.com/CSC000022359
eMolecules	536592	https://orderbb.emolecules.com/search/#?query=536592
Enamine	BBV-40194417	http://www.enaminestore.com/catalog/BBV-40194417
Enamine	EN300-240218	https://www.enaminestore.com/catalog/EN300-240218
eNovation Chemicals	D748576	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D748576&searchbtn.x=0&searchbtn.y=0
Fluorochem	496498	http://www.fluorochem.co.uk/Products/Product?code=496498
Hairui	HR143730	http://www.hairuichem.com/en/product/search.do?q=HR143730
KeyOrganics	AS-58497	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-58497
Lab Network	LN00197993	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00197993
Life Chemicals	F9995-1274	https://shop.lifechemicals.com/2/F9995-1274
Matrix Scientific	139031	http://www.matrixscientific.com/139031.html
mcule	MCULE-1086101121	https://mcule.com/MCULE-1086101121/
MedChem Express	HY-N7138	https://www.medchemexpress.com/search.html?q=HY-N7138&ft=&fa=&fp=
Molnova	M15273	https://www.molnova.com/en/serch-list.html?keywords=M15273
MolPort	MolPort-003-666-393	https://www.molport.com/shop/molecule-link/MolPort-003-666-393
MuseChem	R070276	https://www.musechem.com/product/R070276.html
PI Chemicals	PI-27778	http://www.pipharm.com/catalog_products/PI-27778.html
Ryan Scientific	Oltipraz	https://ryansci.com/products?q=Oltipraz&list_q=&search_type=exact
Selleck Chemicals	S5729	http://www.selleckchem.com/search.html?searchDTO.searchParam=S5729
TargetMol	T1427	https://www.targetmol.com/search?keyword=T1427
Tetrahedron	TS22326	http://www.thsci.com/search.do?q=TS22326
Toronto Research Chemicals	P320975	https://www.trc-canada.com/product-detail/?CatNum=P320975
Vesino Industrial Co Ltd	VZ33514	http://www.vsnchem.com/search.do?a=s&psize=20&q=VZ33514
Wonderchem	WD06FLD	http://www.wonder-chem.com/search.html?text=WD06FLD

PubMed

Title	Date	PubMed
Plasma pentosidine and total homocysteine levels in relation to change in common carotid intima-media area in the first year of dialysis therapy.	2006-12	17176913
Injectable and self-curing composites of acrylic/bioactive glass and drug systems. A histomorphometric analysis of the behaviour in rabbits.	2006-03	16260032
Injectable self-curing bioactive acrylic-glass composites charged with specific anti-inflammatory/analgesic agent.	2004-05	14741603

Patents

Sample Use Guides

In Vivo Use Guide

The daily dose of fosfosal was 1 gram three times a day, once every 6-8 hours.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

DISODIUM SALICYLPHOSPHATE

Preferred Name

English

FOSFOSAL

Official Name

English

FOSFOSAL [MART.]

Common Name

English

SALICYLIC ACID PHOSPHATE DISODIUM SALT

Brand Name

English

fosfosal [INN]

Common Name

English

SALICYLIC ACID DIHYDROGEN PHOSPHATE

Systematic Name

English

AYDOLID

Brand Name

English

Fosfosal [WHO-DD]

Common Name

English

NSC-46475

Code

English

FOSFOSAL [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257