Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H23N5O5 |
Molecular Weight | 389.4057 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C2=C(N(CCCNCC(O)C3=CC(O)=CC(O)=C3)C=N2)C(=O)N(C)C1=O
InChI
InChIKey=WVLAAKXASPCBGT-UHFFFAOYSA-N
InChI=1S/C18H23N5O5/c1-21-16-15(17(27)22(2)18(21)28)23(10-20-16)5-3-4-19-9-14(26)11-6-12(24)8-13(25)7-11/h6-8,10,14,19,24-26H,3-5,9H2,1-2H3
Reproterol is a short-acting β2 adrenoreceptor agonist used in the treatment of asthma. Reproterol increases the generation of cAMP in isolated peripheral blood monocytes in vitro more effectively than does orciprenaline. In the presence of the highly potent but nonselective ß-antagonist, propranolol, the cAMP-generating action of reproterol was inhibited only partially. Reproterol has gained wide use when it was licensed as a fixed combination therapy with cromoglycate. Until today, the bronchodilator effects of reproterol and the bronchoprotective and anti-inflammatory actions of cromoglycate combined in one inhaler remain the successful fixed combination of a disease-modifying and symptomatic drug for the treatment of asthma.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: Phosphodiesterase, mouse Sources: https://www.ncbi.nlm.nih.gov/pubmed/15219266 |
52.0 µM [IC50] |
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Classification Tree | Code System | Code | ||
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WHO-ATC |
R03CC14
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NCI_THESAURUS |
C48149
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WHO-VATC |
QR03CC14
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WHO-ATC |
R03AC15
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WHO-VATC |
QR03AK05
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WHO-ATC |
R03AK05
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NCI_THESAURUS |
C319
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WHO-VATC |
QR03AC15
Created by
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Code System | Code | Type | Description | ||
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SUB10283MIG
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REPROTEROL
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25654
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DB12846
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C014792
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258-956-1
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C152194
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11941YC6RN
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m9529
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CHEMBL1095607
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35373
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54063-54-6
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100000080550
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DTXSID8023553
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2368
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3501
Created by
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)