FIDEXABAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H24F2N6O5
Molecular Weight	526.4921
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(CC(O)=O)C1=C(F)C(OC2=CC(=CC=C2)C3=NCCN3C)=NC(OC4=CC(=CC=C4O)C(N)=N)=C1F

InChI

InChIKey=NPNSVNGQJGRSNR-UHFFFAOYSA-N

InChI=1S/C25H24F2N6O5/c1-32-9-8-30-23(32)14-4-3-5-15(10-14)37-24-19(26)21(33(2)12-18(35)36)20(27)25(31-24)38-17-11-13(22(28)29)6-7-16(17)34/h3-7,10-11,34H,8-9,12H2,1-2H3,(H3,28,29)(H,35,36)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10813384 | https://www.ncbi.nlm.nih.gov/pubmed/11740955

FIDEXABAN is a potent inhibitor of coagulation factor Xa with anticoagulant activity. Like other factor Xa inhibitors, it prevents thrombus formation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits.	2000 May	10813384
FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834.	2001 Aug 15	11562339
The antithrombotic effects of CI-1031 (ZK-807834) and enoxaparin in a canine electrolytic injury model of arterial and venous thrombosis.	2001 Dec 7	11740955
A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs.	2001 Feb	11160645
Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031).	2002 Feb 15	12031830

Patents

Sample Use Guides

In Vitro Use Guide

Fidexaban (ZK-807834) in the range of 0.3-0.5 microM prolonged prothrombin time and activated partial thromboplastin time twofold without affecting thrombin time. ZK-807834 inhibited Factor Xa in clot-bound prothrombinase with an average IC50 of 10+/-7 (S.D.) nM.

Name

Type

Language

FIDEXABAN

Official Name

English

ZK807834

Code

English

ZK-807834

Code

English

fidexaban [INN]

Common Name

English

CI-1031

Code

English

[[2-(5-Carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]methylamino]acetic acid

Systematic Name

English

FIDEXABAN [USAN]

Common Name

English

GLYCINE, N-(2-(5-(AMINOIMINOMETHYL)-2-HYDROXYPHENOXY)-6-(3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL)PHENOXY)-3,5-DIFLUORO-4-PYRIDINYL)-N-METHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C263