DRAFLAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C30H33Cl2F2N5O2
Molecular Weight	604.518
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1CN(CCCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CCN1CC(=O)NC4=C(Cl)C=C(N)C=C4Cl

InChI

InChIKey=IWMYIWLIESDFRZ-UHFFFAOYSA-N

InChI=1S/C30H33Cl2F2N5O2/c31-25-15-23(35)16-26(32)29(25)37-28(40)18-39-14-13-38(17-27(39)30(36)41)12-2-1-3-24(19-4-8-21(33)9-5-19)20-6-10-22(34)11-7-20/h4-11,15-16,24,27H,1-3,12-14,17-18,35H2,(H2,36,41)(H,37,40)

HIDE SMILES / InChI

Description
Sources: DOI: 10.1016/B978-008055232-3.61656-3 | https://adisinsight.springer.com/drugs/800002171 | https://www.ncbi.nlm.nih.gov/pubmed/24162843

Draflazine is a member of the lidoflazine. Draflazine is a potent inhibitor of equilibrative nucleoside transporters (ENTs). It is more selective for ENT1 relative to ENT2. Draflazine is cardioprotective due to potentiation of receptor-mediated effects of adenosine in the ischemic myocardium. It has also been tested for enhancing cardiac functionality in isolated hearts during storage or transport for transplant operations. Draflazine exhibits overactive bladder activity. It is not yet approved for clinical use.

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Single dose - 10 mg/kg

Route of Administration: Other

Name

Type

Language

DRAFLAZINE

Official Name

English

(±)-4'-AMINO-4-(5,5-BIS(P-FLUOROPHENYL)PENTYL)-2-CARBAMOYL-2',6'-DICHLORO-1-PIPERAZINEACETANILIDE

Common Name

English

2-(AMINOCARBONYL)-N-(4-AMINO-2,6-DICHLOROPHENYL)-4-(5,5-BIS(4-FLUOROPHENYL)PENTYL)-1-PIPERAZINEACETAMIDE

Systematic Name

English

R70380

Code

English

R-70380

Code

English

R-75231

Code

English

(±)-2-(AMINOCARBONYL)-N-(4-AMINO-2,6-DICHLOROPHENYL)-4-(5,5-BIS(4-FLUOROPHENYL)PENTYL)-1-PIPERAZINE-ACETAMIDE

Systematic Name

English

draflazine [INN]

Common Name

English

R75231

Code

English

1-PIPERAZINEACETAMIDE, 2-(AMINOCARBONYL)-N-(4-AMINO-2,6-DICHLOROPHENYL)-4-(5,5-BIS(4-FLUOROPHENYL)PENTYL)-, (±)-

Systematic Name

English

DRAFLAZINE [USAN]

Common Name

English

1-PIPERAZINEACETAMIDE, 2-(AMINOCARBONYL)-N-(4-AMINO-2,6-DICHLOROPHENYL)-4-(5,5-BIS(4-FLUOROPHENYL)PENTYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1327