Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C49H76O3 |
| Molecular Weight | 713.1259 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 4 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCC2=C(O1)C(C)=C(C)C(OC(=O)\C=C(C)\C=C\C=C(C)\C=C\C3=C(C)CCCC3(C)C)=C2C
InChI
InChIKey=RIQIJXOWVAHQES-UNAKLNRMSA-N
InChI=1S/C49H76O3/c1-34(2)19-14-20-35(3)21-15-22-36(4)25-17-31-49(13)32-29-43-42(10)46(40(8)41(9)47(43)52-49)51-45(50)33-38(6)24-16-23-37(5)27-28-44-39(7)26-18-30-48(44,11)12/h16,23-24,27-28,33-36H,14-15,17-22,25-26,29-32H2,1-13H3/b24-16+,28-27+,37-23+,38-33+/t35-,36-,49-/m1/s1
DescriptionCurator's Comment: Decsription was created based on several sources including http://www.ncbi.nlm.nih.gov/pubmed/9250786 and https://www.jstage.jst.go.jp/article/skinresearch1959/36/2/36_2_209/_pdf
Curator's Comment: Decsription was created based on several sources including http://www.ncbi.nlm.nih.gov/pubmed/9250786 and https://www.jstage.jst.go.jp/article/skinresearch1959/36/2/36_2_209/_pdf
Tocopheryl retinoate (tocoretinate) is an alpha-tocopherol ester of all-trans retinoic acid (ATRA) and safely used to treat skin ulcers. Tocopheryl retinoate stimulates the formation of granulation tissue in the ulcer, and enhances the migration of guinea pig macrophages and stimulates the proliferation of human skin fibroblasts. It is usually used to treat pressure ulcer (bedsore) and skin ulcer (burn ulcer, diabetic ulcer, leg ulcer). Topical application of tocoretinate reduced the clinical symptoms of lichen amyloidosis and macular amyloidosis, and normalized disturbed epidermal differentiation.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2055 |
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Target ID: CHEMBL2008 |
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Target ID: CHEMBL2003 |
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Target ID: P02461|||Q6LDB3|||Q9UC91 Gene ID: 1281.0 Gene Symbol: COL3A1 Target Organism: Homo sapiens (Human) |
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Target ID: P02462 Gene ID: 1282.0 Gene Symbol: COL4A1 Target Organism: Homo sapiens (Human) |
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Target ID: P02452|||Q15176|||Q9UML6 Gene ID: 1277.0 Gene Symbol: COL1A1 Target Organism: Homo sapiens (Human) |
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Target ID: CHEMBL3810 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Olcenon Ointment 0.25% Approved UseUsually used to treat pressure ulcer (bedsore) and skin ulcer (burn ulcer, diabetic ulcer, leg ulcer) |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
Sample Use Guides
In general, after cleaning up the affected area, put an appropriate amount of Tocopheryl retinoate ointment on gauze according to the symptom/size of the affected area and apply, or apply directly to the affected area, once to twice a day.
Route of Administration:
Topical
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5282180
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40516-49-2
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0WN694NBMM
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0WN694NBMM
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1313259
Created by
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SUBSTANCE RECORD
