The recommended dosage of STROMECTOL for the treatment of strongyloidiasis is a single oral dosedesigned to provide approximately 200 mkg of ivermectin per kg of body weight (~20mkg of Ivermectin B1B). The recommended dosage of STROMECTOL for the treatment of onchocerciasis is a single oral dose designed to provide approximately 150 mkg of ivermectin per kg of body weight (~15mkg of Ivermectin B1B).

Individual adult O. circumcincta (males and females at random) were manually picked from the storage container with a small forceps, washed and placed in groups of 7–8 individuals into the wells of a 24-well plate (Falcon Tissue Plates). For testing the effects of Ivermectin B1B, each well contained in a total volume of 1•5 mL the worms, RPMI medium and a different concentration of the drug at 10-fold dilutions in different wells. The worms were incubated in these plates for 24 h in an atmosphere containing 5%CO2 at 37 °C. Following incubation, the worms from each well were placed into single glass tubes (inner diameter 6 mm) containing the incubation medium (1•5mL) and enough fresh medium to bring the meniscus in line with the window of the light source in the Micromotility Meter The tubes were maintained in a 37 °C warm water bath. For the measurements, a single tube was placed in the channel of the Micromotility Meter (also held at 37 °C). After a settling period of 10 s, motility was measured for 50–60 s. Dead helminths generated a reading comparable to those obtained from medium alone.