Details
Stereochemistry | ACHIRAL |
Molecular Formula | C11H14O3 |
Molecular Weight | 194.2271 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)COC(=O)C1=CC=C(O)C=C1
InChI
InChIKey=XPJVKCRENWUEJH-UHFFFAOYSA-N
InChI=1S/C11H14O3/c1-8(2)7-14-11(13)9-3-5-10(12)6-4-9/h3-6,8,12H,7H2,1-2H3
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Inactive ingredient | surmontil Approved UseSurmontil is indicated for the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. In studies with neurotic outpatients, the drug appeared to be equivalent to amitriptyline in the less-depressed patients but somewhat less effective than amitriptyline in the more severely depressed patients. In hospitalized depressed patients, trimipramine and imipramine were equally effective in relieving depression. Launch Date1979 |
PubMed
Title | Date | PubMed |
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[Competitive binding of some alkyl p-hydroxybenzoates to human estrogen receptor alpha and beta]. | 2000 Dec |
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ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR. | 2001 Dec |
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Oestrogenic activity of isobutylparaben in vitro and in vivo. | 2002 Jul-Aug |
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Oestrogenic activity of benzylparaben. | 2003 Jan-Feb |
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Parabens as urinary biomarkers of exposure in humans. | 2006 Dec |
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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[Simultaneous determination of 7 kinds of preservatives and saccharin in foods with HPLC, and identification with LC/MS/MS]. | 2007 Dec |
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Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. | 2008 |
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Simultaneous determination of 21 preservatives in cosmetics by ultra performance liquid chromatography. | 2008 Oct |
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Underarm antiperspirants/deodorants and breast cancer. | 2009 |
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Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats. | 2009 Aug |
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Parabens in male infertility-is there a mitochondrial connection? | 2009 Jan |
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An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. | 2009 Nov |
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Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats. | 2009 Oct |
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Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats. | 2010 |
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In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay. | 2010 Apr |
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Mixture effects of endocrine disrupting compounds in vitro. | 2010 Apr |
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Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression. | 2010 Apr |
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Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model. | 2010 Jun |
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Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006. | 2010 May |
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Additional effects of bisphenol A and paraben on the induction of calbindin-D(9K) and progesterone receptor via an estrogen receptor pathway in rat pituitary GH3 cells. | 2012 Oct |
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Comparative study on transcriptional activity of 17 parabens mediated by estrogen receptor α and β and androgen receptor. | 2013 Jul |
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NCI_THESAURUS |
C92608
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4247-02-3
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C92610
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SUB36797
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C471067
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SUBSTANCE RECORD