Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H12F7N5S |
Molecular Weight | 415.332 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NC2=NC(=NN2C(NC3=CC=C(C=C3)S(F)(F)(F)(F)F)=C1)C(C)(F)F
InChI
InChIKey=OIZSVTOIBNSVOS-UHFFFAOYSA-N
InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3
DSM265 is an experimental antimalarial that selectively inhibits the parasite dihydroorotate dehydrogenase (DHODH). DSM265 is the first DHODH inhibitor to reach clinical development for treatment of malaria. DSM265 is highly selective toward DHODH of the malaria parasite Plasmodium, efficacious against both blood and liver stages of P. falciparum, and active against drug-resistant parasite isolates. The only possible DSM265-related adverse event was a moderate transient elevation in serum bilirubin.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL3486 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21696174 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28363637
Single dose of 400 mg
Route of Administration:
Oral
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FDA ORPHAN DRUG |
598417
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0Q42P4YI6B
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1282041-94-4
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DB12397
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admin on Sat Dec 16 11:44:49 GMT 2023 , Edited by admin on Sat Dec 16 11:44:49 GMT 2023
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ACTIVE MOIETY