AZAPETINE PHOSPHATE

US Previously Marketed

First approved in 1954

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17N.H3O4P
Molecular Weight	333.3188
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OP(O)(O)=O.C=CCN1CC2=C(C=CC=C2)C3=C(C1)C=CC=C3

InChI

InChIKey=SRNXLNNBIYZIHB-UHFFFAOYSA-N

InChI=1S/C17H17N.H3O4P/c1-2-11-18-12-14-7-3-5-9-16(14)17-10-6-4-8-15(17)13-18;1-5(2,3)4/h2-10H,1,11-13H2;(H3,1,2,3,4)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13319017 | https://www.ncbi.nlm.nih.gov/pubmed/13190610 | https://www.ncbi.nlm.nih.gov/pubmed/44455

AZAPETINE, a benzazepine derivative, is an alpha-1 adrenoceptor antagonist. It is a potent arterial vasodilator in the treatment of peripheral vascular diseases.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peripheral Vascular Diseases 3 Sources: https://books.google.ru/books?id=_J2ti4EkYpkC&pg=PA473&lpg=PA473&dq=Ilidar retrieved from Pharmaceutical Manufacturing Encyclopedia, 3rd Edition: William Andrew Publishing, p.473	Primary		Approved 8429	Ilidar Approved Use Peripheral vascular disease Launch Date 1954

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1S17
Alfa Chemistry	130-83-6
Alfa Chemistry	146-36-1
BLD Pharm	BD108020	http://www.bldpharm.com/products/146-36-1.html
BOC Sciences	130-83-6
BOC Sciences	146-36-1
ChemTik	CTK4C4932
Chemieliva Pharmaceutical Co., Ltd	PBCM0294794
Chemspace	CSSS00026123841	https://chem-space.com/CSSS00026123841
Compound Cloud	8966
Enamine	Z1015206996
MolPort	MolPort-006-111-060
MuseChem	M070348
MuseChem	M070494
NCI Plated 2007	312320
NovoSeek	8966
Parchem	59153	https://www.parchem.com/chemical-supplier-distributor/5H-Dibenz[C-E]Azepine--6-7-Dihydro-6-(2-Propenyl)--059153.aspx
Sinfoo Biotech	S018460	http://www.sinfoobiotech.com/product/1021858
Smolecule	S572384	https://www.smolecule.com/products/s572384
Tetrahedron	TS56692
ZINC	ZINC000001481977	http://zinc15.docking.org/substances/ZINC000001481977
eMolecules	45645622
mcule	MCULE-7577485718	https://mcule.com/MCULE-7577485718/

PubMed

Title	Date	PubMed
Clinical trial of ilidar; a new dibenzazepine adrenergic blocking drug, in the treatment of peripheral vascular diseases and miscellaneous complaints.	1954 Sep	13190610
Clinical effects of azapetine (ilidar) on peripheral arterial disease.	1956 Jun 30	13319017
DDT-induced myoclonus: serotonin and alpha noradrenergic interaction.	1979 Feb	37558
An in vivo model for investigating alpha 1- and alpha 2-receptors in the CNS: studies with mianserin.	1979 Nov	44455
Furter investigations on the interaction between alpha-adrenoceptor antagonists and the central hypotensive effect of clonidine in rats, rabbits and dogs.	1980 Jul	6106536

Patents

Name

Type

Language

AZAPETINE PHOSPHATE

Common Name

English

ILIDAR

Brand Name

English

6,7-DIHYDRO-6-(2-PROPENYL)-5H-DIBENZ(C,E)AZEPINE PHOSPHATE

Systematic Name

English

5H-DIBENZ(C,E)AZEPINE, 6,7-DIHYDRO-6-(2-PROPENYL)-, PHOSPHATE (1:1)

Systematic Name

English

6-ALLYL-6,7-DIHYDRO-5H-DIBENZ(C,E)AZEPINE PHOSPHATE

Systematic Name

English

5H-DIBENZ(C,E)AZEPINE, 6,7-DIHYDRO-6-ALLYL-, PHOSPHATE (1:1)

Systematic Name

English

Azapetine phosphate [WHO-DD]

Common Name

English

NSC-312320

Code

English

AZAPETINE PHOSPHATE [MART.]

Common Name

English

RO-2-3248

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29713