AZAPETINE PHOSPHATE

US Previously Marketed

First approved in 1954

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17N.H3O4P
Molecular Weight	333.3188
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OP(O)(O)=O.C=CCN1CC2=CC=CC=C2C3=CC=CC=C3C1

InChI

InChIKey=SRNXLNNBIYZIHB-UHFFFAOYSA-N

InChI=1S/C17H17N.H3O4P/c1-2-11-18-12-14-7-3-5-9-16(14)17-10-6-4-8-15(17)13-18;1-5(2,3)4/h2-10H,1,11-13H2;(H3,1,2,3,4)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13319017 | https://www.ncbi.nlm.nih.gov/pubmed/13190610 | https://www.ncbi.nlm.nih.gov/pubmed/44455

AZAPETINE, a benzazepine derivative, is an alpha-1 adrenoceptor antagonist. It is a potent arterial vasodilator in the treatment of peripheral vascular diseases.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peripheral Vascular Diseases 3 Sources: https://books.google.ru/books?id=_J2ti4EkYpkC&pg=PA473&lpg=PA473&dq=Ilidar retrieved from Pharmaceutical Manufacturing Encyclopedia, 3rd Edition: William Andrew Publishing, p.473	Primary		Approved 8583	Ilidar Approved Use Peripheral vascular disease Launch Date 1954

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1S17
Alfa Chemistry	130-83-6
Alfa Chemistry	146-36-1
BLD Pharm	BD108020	http://www.bldpharm.com/products/146-36-1.html
BOC Sciences	130-83-6
BOC Sciences	146-36-1
Chemieliva Pharmaceutical Co., Ltd	PBCM0294794
Chemspace	CSSS00026123841	https://chem-space.com/CSSS00026123841
ChemTik	CTK4C4932
Compound Cloud	8966
eMolecules	45645622
Enamine	Z1015206996
mcule	MCULE-7577485718	https://mcule.com/MCULE-7577485718/
MolPort	MolPort-006-111-060
MuseChem	M070348
MuseChem	M070494
NCI Plated 2007	312320
NovoSeek	8966
Parchem	59153	https://www.parchem.com/chemical-supplier-distributor/5H-Dibenz[C-E]Azepine--6-7-Dihydro-6-(2-Propenyl)--059153.aspx
Sinfoo Biotech	S018460	http://www.sinfoobiotech.com/product/1021858
Smolecule	S572384	https://www.smolecule.com/products/s572384
Tetrahedron	TS56692
ZINC	ZINC000001481977	http://zinc15.docking.org/substances/ZINC000001481977

PubMed

Title	Date	PubMed
Furter investigations on the interaction between alpha-adrenoceptor antagonists and the central hypotensive effect of clonidine in rats, rabbits and dogs.	1980-07	6106536
An in vivo model for investigating alpha 1- and alpha 2-receptors in the CNS: studies with mianserin.	1979-11	44455
DDT-induced myoclonus: serotonin and alpha noradrenergic interaction.	1979-02	37558
Clinical effects of azapetine (ilidar) on peripheral arterial disease.	1956-06-30	13319017
Clinical trial of ilidar; a new dibenzazepine adrenergic blocking drug, in the treatment of peripheral vascular diseases and miscellaneous complaints.	1954-09	13190610

Patents

Name

Type

Language

AZAPETINE PHOSPHATE

Common Name

English

NSC-312320

Preferred Name

English

ILIDAR

Brand Name

English

6,7-DIHYDRO-6-(2-PROPENYL)-5H-DIBENZ(C,E)AZEPINE PHOSPHATE

Systematic Name

English

5H-DIBENZ(C,E)AZEPINE, 6,7-DIHYDRO-6-(2-PROPENYL)-, PHOSPHATE (1:1)

Systematic Name

English

6-ALLYL-6,7-DIHYDRO-5H-DIBENZ(C,E)AZEPINE PHOSPHATE

Systematic Name

English

5H-DIBENZ(C,E)AZEPINE, 6,7-DIHYDRO-6-ALLYL-, PHOSPHATE (1:1)

Systematic Name

English

Azapetine phosphate [WHO-DD]

Common Name

English

AZAPETINE PHOSPHATE [MART.]

Common Name

English

RO-2-3248

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29713