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Details

Stereochemistry ABSOLUTE
Molecular Formula C39H69NO12
Molecular Weight 743.9647
Optical Activity UNSPECIFIED
Defined Stereocenters 17 / 17
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IDREMCINAL

SMILES

[H][C@@]2(O[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C3=C(C)C[C@@](C)(O3)[C@]([H])(O[C@@H]4O[C@H](C)C[C@@H]([C@H]4O)N(C)C(C)C)[C@H]2C

InChI

InChIKey=FPBKIOZMKHHNLL-CBUZSSJJSA-N
InChI=1S/C39H69NO12/c1-15-27-39(12,45)32(42)22(6)30-20(4)17-38(11,52-30)34(51-36-29(41)26(16-21(5)47-36)40(13)19(2)3)23(7)31(24(8)35(44)49-27)50-28-18-37(10,46-14)33(43)25(9)48-28/h19,21-29,31-34,36,41-43,45H,15-18H2,1-14H3/t21-,22+,23+,24-,25+,26+,27-,28+,29-,31+,32-,33+,34-,36+,37-,38-,39-/m1/s1

HIDE SMILES / InChI
Idremcinal (previously known as EM574), a motilin receptor agonist, has been studied for the treatment of gastritis. The drug was involved in phase II in Japan for the treatment of chronic gastritis and Gastro-esophageal reflux in the USA. However, the development of the drug was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum.
1994 Oct
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity.
1996 Aug

Sample Use Guides

Thirty healthy volunteers received one of five oral doses of EM574 (IDREMCINAL) (5, 10, 20, 30 mg and placebo) in a randomized, double-blind, five-period, cross-over design; each dosing period was separated by 1-wk washout.
Route of Administration: Oral
Name Type Language
IDREMCINAL
INN   USAN  
USAN   INN  
Official Name English
8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-isopropylerythromycin
Common Name English
EM-574
Code English
8,9-DIDEHYDRO-N-DEMETHYL-9-DEOXO-6-DEOXY-6,9-EPOXY-N-(1-METHYLETHYL)ERTHROMYCIN
Common Name English
idremcinal [INN]
Common Name English
IDREMCINAL [USAN]
Common Name English
EM574
Code English
Code System Code Type Description
NCI_THESAURUS
C166426
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
CAS
110480-13-2
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
PUBCHEM
84019
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
INN
7837
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID10891360
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
MESH
C090116
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
USAN
JJ-41
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
SMS_ID
300000034232
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
FDA UNII
0M6189XXJN
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY
ChEMBL
CHEMBL2103968
Created by admin on Sat Dec 16 18:00:40 UTC 2023 , Edited by admin on Sat Dec 16 18:00:40 UTC 2023
PRIMARY