U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C34H49N7O8
Molecular Weight 683.795
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZEP-3

SMILES

CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CCC(=O)N3)C(O)=O

InChI

InChIKey=RFDMQNKNNCOSFL-FWEHEUNISA-N
InChI=1S/C34H49N7O8/c1-2-3-4-5-6-14-29(43)36-17-10-9-13-25(34(48)49)39-32(46)26(18-21-20-37-23-12-8-7-11-22(21)23)40-33(47)27(19-28(35)42)41-31(45)24-15-16-30(44)38-24/h7-8,11-12,20,24-27,37H,2-6,9-10,13-19H2,1H3,(H2,35,42)(H,36,43)(H,38,44)(H,39,46)(H,40,47)(H,41,45)(H,48,49)/t24-,25-,26-,27-/m0/s1

HIDE SMILES / InChI
SIS Shulov Innovative Science is developing ZEP 3, a short synthetic peptide. This drug was studied in phase II clinical trial for the treatment of cold sores (Herpes labialis). In addition, was shown that ZEP-3 exhibited analgesic activity in various indications such as osteoarthritis, herpes labialis and ocular pain. In parallel, the company is planning a phase II clinical study in atopic dermatitis.

Approval Year

Sample Use Guides

ZEP-3 ointment 1.0%
Route of Administration: Transdermal
Name Type Language
ZEP-3
Common Name English
L-LYSINE, 5-OXO-L-PROLYL-L-ASPARAGINYL-L-TRYPTOPHYL-N6-(1-OXOOCTYL)-
Systematic Name English
(2S)-2-(((2S)-2-(((2S)-4-AMINO-4-OXO-2-(((2S)-5-OXOPYRROLIDINE-2-CARBONYL)AMINO)BUTANOYL)AMINO)-3-(1H-INDOL-3-YL)PROPANOYL)AMINO)-6-(OCTANOYLAMINO)HEXANOIC ACID
Systematic Name English
Code System Code Type Description
CAS
1026276-22-1
Created by admin on Sat Dec 16 12:09:19 GMT 2023 , Edited by admin on Sat Dec 16 12:09:19 GMT 2023
PRIMARY
FDA UNII
0L93DJI2CP
Created by admin on Sat Dec 16 12:09:19 GMT 2023 , Edited by admin on Sat Dec 16 12:09:19 GMT 2023
PRIMARY
PUBCHEM
9896260
Created by admin on Sat Dec 16 12:09:19 GMT 2023 , Edited by admin on Sat Dec 16 12:09:19 GMT 2023
PRIMARY