Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H10N2O2S2 |
Molecular Weight | 242.318 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)NC1=C2SSC=C2N(C)C1=O
InChI
InChIKey=UGZYFXMSMFMTSM-UHFFFAOYSA-N
InChI=1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/24835149
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24835149
Aureothricin is the earliest reported Dithiolopyrrolone (DTP). It was first isolated in 1948 by Umezawa and co-workers as a yellow crystalline solid from Streptomyces strain no. 26A related to Nocardia farcinica (referred to as A. farcinicus in the original manuscript). Notably, the compound was characterized by potent antibiotic activity against E. coli and a strong UV absorption maximum at 388 nm, distinctive of the pyrrothine core. Aureothricin is a known inhibitor of RNA Polymerase.
Originator
Approval Year
Targets
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Target ID: CHEMBL2364672 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4597739 |
Conditions
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DTXSID60205993
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574-95-8
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68460
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C010684
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0KX00L19Q2
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m2141
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156452
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SUBSTANCE RECORD