Aureothricin is the earliest reported Dithiolopyrrolone (DTP). It was first isolated in 1948 by Umezawa and co-workers as a yellow crystalline solid from Streptomyces strain no. 26A related to Nocardia farcinica (referred to as A. farcinicus in the original manuscript). Notably, the compound was characterized by potent antibiotic activity against E. coli and a strong UV absorption maximum at 388 nm, distinctive of the pyrrothine core. Aureothricin is a known inhibitor of RNA Polymerase.