U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H29ClO3
Molecular Weight 364.906
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOGESTONE

SMILES

[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C=C(Cl)C4=C[C@@H](O)CC[C@]34C

InChI

InChIKey=WZTUZRFSDWXDRM-IAGOJMRCSA-N
InChI=1S/C21H29ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,13-16,24-25H,4-9H2,1-3H3/t13-,14+,15-,16-,19+,20-,21-/m0/s1

HIDE SMILES / InChI
Clogestone Acetate (AY-11440) is a steroidal progestin that was synthesized in 1964 and was investigated as a progestin-only contraceptive but was never marketed.

Approval Year

TargetsConditions

Conditions

PubMed

PubMed

TitleDatePubMed
Progestational activity of a new diacetate progesterone derivative.
1970 Aug
[Mechanism of action of progestins in the treatment of hormone-dependent breast cancer (author's transl)].
1975 Nov-Dec
Interference of gestagens and androgens with rat uterine oestrogen receptors.
1978 Apr
Effects of hormonal and nonhormonal contraceptives on lactation and incidence of pregnancy.
1986 Mar
Patents

Patents

Sample Use Guides

Clogestone Acetate (AY-11440) was tested at several doses for 3 cycles in 14 postmenopausal women and 7 ovulating women. Patients and doses were the following: 14 postmenopausal women with vasomotor syndrome who were given 1.25 mg Premarin for 21 days and .1 mg, 1 mg, or 3 mg AY-11440, for the last 10 days of a cycle; and 7 cycling women seeking contraception, given .1, .5, or 1 mg AY-11440 daily from Day 5-25.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
CLOGESTONE
INN  
INN  
Official Name English
PREGNA-4,6-DIENE-20-ONE, 3,17-DIHYDROXY-6-CHLORO-
Systematic Name English
6-CHLORO-3.BETA.,17-DIHYDROXYPREGNA-4,6-DIEN-20-ONE
Systematic Name English
clogestone [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C776
Created by admin on Sat Dec 16 17:25:15 GMT 2023 , Edited by admin on Sat Dec 16 17:25:15 GMT 2023
Code System Code Type Description
FDA UNII
0I88K7V2TF
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PRIMARY
ChEMBL
CHEMBL2106484
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WIKIPEDIA
Clogestone
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MESH
C100090
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PUBCHEM
20055454
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EPA CompTox
DTXSID60173865
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EVMPD
SUB06714MIG
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SMS_ID
100000084338
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INN
2596
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CAS
20047-75-0
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PRIMARY
NCI_THESAURUS
C80619
Created by admin on Sat Dec 16 17:25:15 GMT 2023 , Edited by admin on Sat Dec 16 17:25:15 GMT 2023
PRIMARY