Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H16N2O4S |
Molecular Weight | 332.374 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(NC(C)=O)C=C2
InChI
InChIKey=AMTPYFGPPVFBBI-UHFFFAOYSA-N
InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)
Acedapsone (4,4′-diacetyldiaminodiphenyl sulfone) is a long-acting intramuscular repository derivative of dapsone. Acedapsone is mainly used as a depot leprostatic agent. The parent compound possesses little activity against M. leprae but is metabolized into active dapsone. Its half-life is 46 days, and that of the derived dapsone is 43 days. A 300-mg intramuscular dose maintains dapsone levels in volunteers above the inhibitory concentration for M. leprae for approximately 100 days. Microbiologic and clinical responses are somewhat slower than those for daily dapsone are. Long-term studies with acedapsone by injection five times yearly have yielded encouraging results. Acedapsone shows promise especially in regions where, or in patients in whom, long-term oral therapy is not practical.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2094118 Sources: http://dx.doi.org/10.1016/S0960-894X(97)00046-2 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3794408
The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days.
Route of Administration:
Intramuscular
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NCI_THESAURUS |
C849
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2719
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Acedapsone
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C76985
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201-028-8
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ACTIVE MOIETY