U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

2023
446
Name Type Language
ISIS-682884 FREE ACID
Preferred Name English
EPLONTERSEN
USAN   INN  
Official Name English
ION-TTR-LRX
Common Name English
DNA, D((2'-O-(2-METHOXYETHYL))M5RU-SP-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))RG-G-SP-T-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-G-SP-A-SP-A-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RU-
Common Name English
ALL-P-AMBO-5-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXOXY))PHOSPHO)-2-O-(2-METHOXYETHYL)-5-METHYL-P-THIOURIDYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)-5-METHYLCYTID
Common Name English
AKCEA-TTR-LRX
Common Name English
EPLONTERSEN [USAN]
Common Name English
IONIS-TTR-LRX
Common Name English
AKCEA TTR LRX
Common Name English
Eplontersen [WHO-DD]
Common Name English
eplontersen [INN]
Common Name English
ION-682884 FREE ACID
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 827521
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
Code System Code Type Description
SMS_ID
300000000461
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
CAS
1637600-16-8
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
NCI_THESAURUS
C175062
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
INN
11482
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
FDA UNII
0GRZ0F5XJ6
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
USAN
GH-148
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
DAILYMED
0GRZ0F5XJ6
Created by admin on Wed Apr 02 00:35:27 GMT 2025 , Edited by admin on Wed Apr 02 00:35:27 GMT 2025
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Deoxyribose (DNA) 1_6-1_15 10 / 20
Linkage Site Range Site Count
Phosphate 1_3-1_6;1_17-1_18 6 / 19
Phosporothioate 1_2;1_7-1_16;1_19-1_20 13 / 19
ACTIVE MOIETY
EPLONTERSEN
SALT/SOLVATE (PARENT)
EPLONTERSEN SODIUM
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966