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Approval Year

2023
455
Name Type Language
EPLONTERSEN
USAN   INN  
Official Name English
ION-TTR-LRX
Common Name English
DNA, D((2'-O-(2-METHOXYETHYL))M5RU-SP-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))RG-G-SP-T-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-G-SP-A-SP-A-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RU-
Common Name English
ISIS-682884 FREE ACID
Code English
ALL-P-AMBO-5-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXOXY))PHOSPHO)-2-O-(2-METHOXYETHYL)-5-METHYL-P-THIOURIDYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)-5-METHYLCYTID
Common Name English
AKCEA-TTR-LRX
Common Name English
EPLONTERSEN [USAN]
Common Name English
IONIS-TTR-LRX
Common Name English
AKCEA TTR LRX
Common Name English
Eplontersen [WHO-DD]
Common Name English
eplontersen [INN]
Common Name English
ION-682884 FREE ACID
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 827521
Created by admin on Sat Dec 16 14:38:59 GMT 2023 , Edited by admin on Sat Dec 16 14:38:59 GMT 2023
Code System Code Type Description
CAS
1637600-16-8
Created by admin on Sat Dec 16 14:38:59 GMT 2023 , Edited by admin on Sat Dec 16 14:38:59 GMT 2023
PRIMARY
NCI_THESAURUS
C175062
Created by admin on Sat Dec 16 14:38:59 GMT 2023 , Edited by admin on Sat Dec 16 14:38:59 GMT 2023
PRIMARY
INN
11482
Created by admin on Sat Dec 16 14:38:59 GMT 2023 , Edited by admin on Sat Dec 16 14:38:59 GMT 2023
PRIMARY
FDA UNII
0GRZ0F5XJ6
Created by admin on Sat Dec 16 14:38:59 GMT 2023 , Edited by admin on Sat Dec 16 14:38:59 GMT 2023
PRIMARY
USAN
GH-148
Created by admin on Sat Dec 16 14:38:59 GMT 2023 , Edited by admin on Sat Dec 16 14:38:59 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Deoxyribose (DNA) 1_6-1_15 10 / 20
Linkage Site Range Site Count
Phosphate 1_3-1_6;1_17-1_18 6 / 19
Phosporothioate 1_2;1_7-1_16;1_19-1_20 13 / 19
ACTIVE MOIETY
EPLONTERSEN
SALT/SOLVATE (PARENT)
EPLONTERSEN SODIUM
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966