Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H15N3O |
Molecular Weight | 265.3098 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=CN=C3
InChI
InChIKey=ZDAZUJBASMCUAK-UHFFFAOYSA-N
InChI=1S/C16H15N3O/c20-16(13-4-3-8-17-10-13)18-9-7-12-11-19-15-6-2-1-5-14(12)15/h1-6,8,10-11,19H,7,9H2,(H,18,20)
Nicotredole (Tryptamide), similarly to ibuprofen and piroxicam, shows anti-inflammatory and analgesic properties. Tryptamide reversed pyrogen-induced hyperthermia in rats, elicited analgesic effects in rats, but not in mice, prolonged the time of hexobarbital sleep in rats and inhibited locomotor activity in rats and mice. Tryptamide has not elicited side effects on the circulatory system of rats and cats.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2095157 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2972998 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1837608
Curator's Comment: Nicotredole was also administered po or ip at a dose 25 mg/kg to rats
https://www.ncbi.nlm.nih.gov/pubmed/12959253
Rats: Plasma and tissue levels of N-3-pyridoyl-tryptamine (Nicotredole) vs. time were determined in rats following iv administration of various doses: 6.25, 12.5, 25.0 and 37.5 mg/kg.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2972998
Unknown
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C257
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C74332
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SUB09248MIG
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DTXSID8045698
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CHEMBL1491339
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7301
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0F1T12OCLX
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65768
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ACTIVE MOIETY