Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H18N2O4S |
Molecular Weight | 358.412 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(CC(O)=O)C2=CC=CN=C2N1CC3=CC=C(C=C3)S(C)(=O)=O
InChI
InChIKey=YOPFAMROKXHVCQ-UHFFFAOYSA-N
InChI=1S/C18H18N2O4S/c1-12-16(10-17(21)22)15-4-3-9-19-18(15)20(12)11-13-5-7-14(8-6-13)25(2,23)24/h3-9H,10-11H2,1-2H3,(H,21,22)
QAV-680 is a pyrrolopyridine derivative patented by Novartis Pharma GmbH as chemoattractant receptor (CRTh2) antagonist for the treatment of an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease. QAV-680 shows low nM potency and excellent selectivity across a range of CRTh2 dependent primary human inflammatory cell assays. In preclinical studies, QAV-680 shows good pharmacokinetic properties (including a suitable escalating dose–exposure relationship) in the rat and mouse and demonstrates efficacy in both mechanistic and allergic disease CRTh2-dependent rodent in vivo models. In 2008-2010 QAV-680 was tested in Phase 2 clinical trials but no further development reports were published.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT01103037
500 mg (5 x 100 mg capsules) four times per day
Route of Administration:
Oral
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1263765-71-4
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DB11658
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CHEMBL2442750
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872365-16-7
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11508736
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0E3D72URPD
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300000041368
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admin on Sat Dec 16 10:58:34 GMT 2023 , Edited by admin on Sat Dec 16 10:58:34 GMT 2023
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ACTIVE MOIETY