Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H8Br4O8 |
| Molecular Weight | 671.867 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=C(OC(=O)\C=C\C(=O)OC2=C(C=C(Br)C=C2Br)C(O)=O)C(Br)=CC(Br)=C1
InChI
InChIKey=INZBQWPDNWVYFR-OWOJBTEDSA-N
InChI=1S/C18H8Br4O8/c19-7-3-9(17(25)26)15(11(21)5-7)29-13(23)1-2-14(24)30-16-10(18(27)28)4-8(20)6-12(16)22/h1-6H,(H,25,26)(H,27,28)/b2-1+
Bis(3,5-dibromosalicyl)fumarate, a compound that reacts with oxyhemoglobin to cross-link the two beta 82 lysine residues and as a result markedly increases the solubility of deoxyhemoglobin S. It was shown that bis(3,5-dibromosalicyl)fumarate effectively inhibited of sickling, that could be used to develop treatments for sickle-cell anemia. Besides this compound possesses anti-inflammatory, analgesic, and antipyretic effects.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparative evaluation of fifteen anti-sickling agents. | 1983 Apr |
|
| The effect of crosslinking by bis(3,5-dibromosalicyl) fumarate on the autoxidation of hemoglobin. | 1989 Sep 15 |
|
| Renal and systemic-hemodynamic response to isovolemic exchange transfusion with hemoglobin cross-linked with bis (3,5-dibromosalicyl) fumarate or albumin. | 1995 Sep |
|
| Structural characterization of human hemoglobin crosslinked by bis(3,5-dibromosalicyl) fumarate using mass spectrometric techniques. | 1997 Dec |
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71337-53-6
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0E07K30TXY
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5997029
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DTXSID301201183
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SUBSTANCE RECORD
