Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.6365 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 6 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCC(O)C(C)(C)O
InChI
InChIKey=FCKJYANJHNLEEP-SRLFHJKTSA-N
InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25?,27-/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/7872065 | https://www.ncbi.nlm.nih.gov/pubmed/3093022
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/7872065 | https://www.ncbi.nlm.nih.gov/pubmed/3093022
24-Hydroxycalcidiol (24,25-dihydroxy vitamin D3) is a circulating metabolite of vitamin D3. 24,25(OH)2D3 functions by activation of Vitamin D receprtor and promotion of ostecalcin expression, but is less effective than other D3 metabolite, 1alpha,25(OH)2D3. There is conflicting evidence on efffect of 24-hydroxycalcidiol on bone metabolism. In several animal studies it was demonstrated that 24-hydroxycalcidiol was able to stimulate calcification of bone and restore the reduction in bone mineral apposition rate. However, no beneficial effect of 24R,25(OH)2D3 treatment of postmenapausal women on bone mineral density or bone loss and calcium metabolism were observed.
Approval Year
Sample Use Guides
In clinical trial for prevention of postmenapausal bone loss, 24-hydroxycalcidiol was administered orally at daily doses of 10 ug.
Route of Administration:
Oral
Dose-dependent induction of the human osteocalcin (hOC) gene promoter by 24R,25(OH)2D3 in the presence of 0.1% serum was demonstrated. Following transfection of pXP2hOC-838/+10 (5 ug/60 mm dish) into MC3T3-E1 cells, various concentrations of 24R,25(OH)2D3 were added, and incubation was carried out for 48 h in alpha-MEM containing 0.1% FBS. The cells were harvested and assayed for luciferase activity. 24R,25(OH)2D3 induced luciferase activity with IC50 of 7.5 nM.
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NCI_THESAURUS |
C941
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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FDA ORPHAN DRUG |
15786
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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6434253
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40013-87-4
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C126931
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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24,25-Dihydroxycholecalciferol
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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0AXX2V8L5Z
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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254-749-5
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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DTXSID501028177
Created by
admin on Sat Dec 16 05:23:04 GMT 2023 , Edited by admin on Sat Dec 16 05:23:04 GMT 2023
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PRIMARY |
PARENT (METABOLITE)
SUBSTANCE RECORD
