PONFIBRATE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H16Cl2O4
Molecular Weight	367.223
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PONFIBRATE

Structure Search

SMILES

CCOC(=O)[C@@H]1OC2=CC=C(Cl)C=C2[C@@H](C)C3=C(O1)C=CC(Cl)=C3

InChI

InChIKey=GIGXYLNNCMPCGM-QHKAPQIGSA-N

InChI=1S/C18H16Cl2O4/c1-3-22-17(21)18-23-15-6-4-11(19)8-13(15)10(2)14-9-12(20)5-7-16(14)24-18/h4-10,18H,3H2,1-2H3/t10-,18-

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/224643 | https://apps.who.int/iris/bitstream/handle/10665/68742/WHO_EDM_QSM_2004.5.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 384, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Ponfibrate is clofibrate derivative. It is an antilipidemic agent with demonstrated hypobetalipoproteinemic effect.

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Lipid decreasing effect of trans-2,10-dichloro-6-ethoxycarbonyl-12-methyldibenzo[d,g] [1,3]dioxocin (EGYT-1932, Crismel)].	1979 Jul	474140
[Hypobetalipoproteinemic effect of trans-2,10-dichloro-6-ethoxycarbonyl-12-methyldibenzo[d,g] [1,3]dioxocin (EGYT-1932, Crismel)].	1979 Jul	224643
HLA class I typing in Egyptian childhood minimal change nephrotic syndrome.	2008 Sep-Oct	18949728

Patents

Patents

Name

Type

Language

PONFIBRATE

Official Name

English

ponfibrate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150

Created by admin on Fri Dec 15 17:20:50 GMT 2023 , Edited by admin on Fri Dec 15 17:20:50 GMT 2023

Code System Code Type Description

ChEMBL

CHEMBL2105244

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EPA CompTox

DTXSID10866311

Created by admin on Fri Dec 15 17:20:50 GMT 2023 , Edited by admin on Fri Dec 15 17:20:50 GMT 2023

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CAS

53341-49-4

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INN

4241

Created by admin on Fri Dec 15 17:20:50 GMT 2023 , Edited by admin on Fri Dec 15 17:20:50 GMT 2023

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SMS_ID

100000081369

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NCI_THESAURUS

C72994

Created by admin on Fri Dec 15 17:20:50 GMT 2023 , Edited by admin on Fri Dec 15 17:20:50 GMT 2023

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FDA UNII

0ARR2L0V0A

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EVMPD

SUB09979MIG

Created by admin on Fri Dec 15 17:20:50 GMT 2023 , Edited by admin on Fri Dec 15 17:20:50 GMT 2023

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ACTIVE MOIETY


					0ARR2L0V0A