ORIDONIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H28O6
Molecular Weight	364.4327
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@]3([H])[C@@]([C@@H]1O)(C(=O)C2=C)[C@]4(O)OC[C@]35[C@@H](O)CCC(C)(C)[C@@]5([H])[C@@H]4O

InChI

InChIKey=SDHTXBWLVGWJFT-XKCURVIJSA-N

InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27344488 | https://www.ncbi.nlm.nih.gov/pubmed/16432862

Oridonin is a diterpenoid purified from Rabdosia rubescens. In traditional Chinese medicine oridonin powder (Donglingcao herb extract) is used as an over-the-counter medicine because of its anti-tumor, anti-bacterial, anti-inflammatory, analgesic and other effects. Oridonin was shown to inhibit many tumor cell lines in vitro and its mechanism of action is mainly explained by inhibition of NF-kB signaling, Keap1-Nrf2-ARE pathway and upregulation of p53/p21 signaling and ROS production.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
NF-kappa B signaling pathway 84 Target ID: map04064 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25121593	Inhibitor 8297
Oxidative Stress 160 Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27344488	Activator 1430
Transcriptional activation by NRF2 1 Target ID: WP3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27344488	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acute myeloid leukemia 136 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27344488	Primary		Preclinical	Unknown Approved Use Unknown
Chronic myeloid leukemia 25 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27344488	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Oridonin inhibits tumor growth in K562 xenograft nude mice at dose 10 and 15 mg/kg.

Route of Administration: Intraperitoneal

In Vitro Use Guide

SGC996 and NOZ cells were treated with oridonin (0.75, 1.5, and 3 μmol/L) and were allowed to form colonies in fresh medium for 14 days. Oridonin completely inhibited cells prolifiration at 30 uM.

Name

Type

Language

ORIDONIN

Official Name

English

ORIDONIN [INCI]

Common Name

English

PURE ORIDONIN

Brand Name

English

ORIDONINE

Common Name

English

KAUR-16-EN-15-ONE, 7.ALPHA.,20-EPOXY-1.ALPHA.,6.BETA.,7,14-TETRAHYDROXY-, (14R)-

Common Name

English

ISODONOL

Common Name

English

NSC-250682

Code

English

KAUR-16-EN-15-ONE, 7,20-EPOXY-1,6,7,14-TETRAHYDROXY-, (1.ALPHA.,6.BETA.,7.ALPHA.,14R)-

Common Name

English

Code System Code Type Description

PUBCHEM

5321010