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Description

trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy.
1967
Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.
1984 Jul 13
The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria.
1986 Dec
Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime.
1987 Jan
Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study.
1987 Jul
Zuclopenthixol and haloperidol/levomepromazine in the treatment of elderly patients with symptoms of aggressiveness and agitation: a double-blind, multi-centre study.
1989
Reversible lithium neurotoxicity at normal serum level may refer to intracranial pathology.
1989 May
[acute dystonias in combined abuse of cocaine and neuroleptics].
1994 Nov 26
Central D2 receptor occupancy and effects of zuclopenthixol acetate in humans.
1995 Nov
Antipsychotic-induced extrapyramidal syndromes. Risperidone compared with low- and high-potency conventional antipsychotic drugs.
2001 Jul
Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms.
2003 Jul
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].
2006 Jun
Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses.
2012 Apr 18
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.
2012 Sep
Paradoxical severe agitation induced by add-on high-doses quetiapine in schizo-affective disorder.
2014 May 15
Patents

Patents

20030015197
10
20030073133
4
Name Type Language
CLOPENTHIXOL
INN   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
NSC-64087
Code English
CLOPENTHIXOL [MI]
Common Name English
AY-62021
Code English
SORDINOL
Brand Name English
Clopenthixol [WHO-DD]
Common Name English
1-PIPERAZINEETHANOL, 4-(3-(2-CHLORO-9H-THIOXANTHEN-9-YLIDENE)PROPYL)-
Common Name English
clopenthixol [INN]
Common Name English
4-[3-(2-Chlorothioxanthen-9-ylidene)propyl]-1-piperazineethanol
Common Name English
CLOPENTHIXOL [USAN]
Common Name English
N-746
Code English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Fri Dec 15 20:38:12 GMT 2023 , Edited by admin on Fri Dec 15 20:38:12 GMT 2023
WHO-VATC QN05AF02
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WHO-ATC N05AF02
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Code System Code Type Description
EVMPD
SUB06736MIG
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PRIMARY
MESH
D003006
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PRIMARY
WIKIPEDIA
Clopenthixol
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NSC
64087
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PRIMARY
CAS
982-24-1
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MERCK INDEX
m3653
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PRIMARY Merck Index
CHEBI
59115
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PRIMARY
ChEMBL
CHEMBL53904
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NCI_THESAURUS
C154301
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DRUG BANK
DB13841
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FDA UNII
0A432D932A
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DRUG CENTRAL
4397
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EPA CompTox
DTXSID9048223
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ECHA (EC/EINECS)
213-566-0
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INN
1315
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All of the following components must be present:
Structure of ZUCLOPENTHIXOL
Structure of CLOPENTHIXOL, TRANS
ACTIVE MOIETY
CLOPENTHIXOL
Definition References
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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