trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.
Approval Year
PubMed
Title | Date | PubMed |
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Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study. | 1987 Jul |
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Central D2 receptor occupancy and effects of zuclopenthixol acetate in humans. | 1995 Nov |
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Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia. | 2005 Jul |
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[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
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Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate. | 2014 Mar |
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