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Details

Stereochemistry ABSOLUTE
Molecular Formula C47H58N12O6
Molecular Weight 887.0402
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EXAMORELIN

SMILES

C[C@H](NC(=O)[C@@H](CC1=C(C)NC2=C1C=CC=C2)NC(=O)[C@@H](N)CC3=CN=CN3)C(=O)N[C@@H](CC4=CNC5=C4C=CC=C5)C(=O)N[C@H](CC6=CC=CC=C6)C(=O)N[C@@H](CCCCN)C(N)=O

InChI

InChIKey=RVWNMGKSNGWLOL-GIIHNPQRSA-N
InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9,12-17,24-26,28,35,38-41,52,54H,10-11,18-23,48-49H2,1-2H3,(H2,50,60)(H,51,53)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,59,65)/t28-,35-,38-,39+,40-,41+/m0/s1

HIDE SMILES / InChI
Examorelin (Hexarelin) is a hexapeptide (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) that stimulates the release of growth hormone lease through binding to the growth hormone secretagogue receptor (GHSR). Hexarelin might have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects. Europeptides and Mediolanum Farmaceutici were developing examorelin for the treatment of somatotropin deficiency.

Approval Year

PubMed

PubMed

TitleDatePubMed
Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.
1994 Mar
The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency.
1995 Sep
Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat.
2010 Apr
Patents

Sample Use Guides

i.v. (1 and 2 ug/kg), sc (1.5 and 3 ug/kg), intranasal (20 ug/kg), and oral (po; 20 and 40 mg)
Route of Administration: Other
Name Type Language
EXAMORELIN
INN   MART.  
INN  
Official Name English
EXAMORELIN [MART.]
Common Name English
examorelin [INN]
Common Name English
L-HISTIDYL-2-METHYL-D-TRYPTOPHYL-L-ALANYL-L-TRYPTOPHYL-D-PHENYLALANYL-L-LYSINAMIDE
Systematic Name English
MF-6003
Code English
HEXARELIN
Common Name English
L-LYSINAMIDE, L-HISTIDYL-2-METHYL-D-TRYPTOPHYL-L-ALANYL-L-TRYPTOPHYL-D-PHENYLALANYL-
Systematic Name English
EP-23905
Code English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-Examorelin
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
NCI_THESAURUS C76358
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C76092
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
FDA UNII
09QF37C617
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
INN
7078
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
CAS
140703-51-1
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL108335
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID401032408
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
WIKIPEDIA
EXAMORELIN
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
EVMPD
SUB07490MIG
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
MESH
C086184
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY
PUBCHEM
6918297
Created by admin on Sat Dec 16 17:39:26 GMT 2023 , Edited by admin on Sat Dec 16 17:39:26 GMT 2023
PRIMARY