Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H16O8 |
Molecular Weight | 408.3576 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C(C1=C(O)C2=C(OC1=O)C=CC=C2)C3=C(O)C4=C(OC3=O)C=CC=C4
InChI
InChIKey=JCLHQFUTFHUXNN-UHFFFAOYSA-N
InChI=1S/C22H16O8/c1-2-28-20(25)15(16-18(23)11-7-3-5-9-13(11)29-21(16)26)17-19(24)12-8-4-6-10-14(12)30-22(17)27/h3-10,15,23-24H,2H2,1H3
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14885082
Curator's Comment: Tromexan was synthesized by von Reinis and Kubik in 1948.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q9BQB6 Gene ID: 79001.0 Gene Symbol: VKORC1 Target Organism: Homo sapiens (Human) |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Tromexan Approved UseThromboses, thrombophlebitis, pulmonary embolisms, thromboembolic episodes at a myocardial infarction, heart failure. |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
40.3 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8351679/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: TRISILOXANE |
ETHYL BISCOUMACETATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
31 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8351679/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
ETHYL BISCOUMACETATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
0.66 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7874379/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
ETHYL BISCOUMACETATE serum | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
2.03 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7874379/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
7-HYDROXY ETHYL BISCOUMACETATE serum | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://go.drugbank.com/drugs/DB08794 |
yes |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13057879
The initial dosage was 900 to 1,800 mg (usually 1,200 or 1,500 mg). The subsequent dosage was judged by daily prothrombin time determinations. Daily maintenance dosage ranged from 300 to 900 mg.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7203295
Unknown
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Classification Tree | Code System | Code | ||
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WHO-ATC |
B01AA08
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WHO-VATC |
QB01AA08
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NCI_THESAURUS |
C263
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EPA PESTICIDE CODE |
11901
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325
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1091
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208-940-5
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m5095
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C75157
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D005017
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SUB07285MIG
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100000082601
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Ethyl biscoumacetate
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548-00-5
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CHEMBL81697
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54685524
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36366
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DB08794
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DTXSID3057771
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08KL644731
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ACTIVE MOIETY
METABOLITE INACTIVE (PARENT)