SORBITAN MONOOLEATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H44O6
Molecular Weight	428.6026
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)COC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

InChIKey=NWGKJDSIEKMTRX-AAZCQSIUSA-N

InChI=1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=173.75 | https://www.drugs.com/inactive/sorbitan-monooleate-461.html | https://www.spectrumchemical.com/OA_HTML/chemical-products_Sorbitan-Monooleate_SPA80.jsp?minisite=10020&respid=22372&phrase=Sorbitan%20Monooleate | https://www.ncbi.nlm.nih.gov/pubmed/25261708 | https://www.ncbi.nlm.nih.gov/pubmed/22197498

Sorbitan monooleate (Span 80) is a partial oleate ester of sorbitol and its mono- and dianhydrides. Sorbitan Monooleate is a nonionic emulsifier and surfactant and used in cosmetics and foods. It is a food additive with the E number E495. Span 80 was suitable as surfactant in the preparation of Poly(divinylbenzene) emulsion-derived (PolyHIPE) solid foam. Anionic nanoparticles based on Span 80 as low-cost, simple and efficient non-viral gene-transfection systems. Sorbitan monooleate is approved by FDA to be used as an emulsifier in polymer dispersions that are used in the clarification of cane or beet sugar juice or liquor in an amount not to exceed 7.5 percent by weight in the final polymer dispersion. The additive is used in an amount not to exceed 0.70 part per million in sugar juice and 1.4 parts per million in sugar liquor.

Approval Year

PubMed

Title	Date	PubMed
Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions.	2001 Jun 19	11397580
Co-surfactant of ethoxylated sorbitan ester and sorbitan monooleate for enhanced flushing of tetrachloroethylene.	2002 Oct	12365839
Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations.	2003 Jul	12885395
Effect of viscosity and concentration of wall former, emulsifier and pore-inducer on the properties of amoxicillin microcapsules prepared by emulsion solvent evaporation.	2005 Mar	15784247
Thymosin-loaded enteric microspheres for oral administration: preparation and in vitro release studies.	2005 Sep 14	16009514
In vitro study of lysozyme in poly(lactide-co-glycolide) microspheres with sucrose acetate isobutyrate.	2006 Dec	16978848
Effect of ciprofloxacin and chloramphenicol on humoral immune response elicited by bovine albumin encapsulated in niosomes.	2007 Aug	17944244
Preparation of tiny biodegradable capsules using electrocapillary emulsification.	2007 Dec	17926169
Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects.	2008	18431669
Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer.	2008 Apr 2	18191509
Formulation and evaluation of flurbiprofen microemulsion.	2008 Jan	18220549
Optimization of process parameters for the extraction of chromium (VI) by emulsion liquid membrane using response surface methodology.	2009 Aug 30	19286319
The effect of component of microemulsion for transdermal delivery of nicardipine hydrochloride.	2010 Dec	20545507
Copper complexed polymer carriers for IgG adsorption.	2010 Dec 1	20817199
Removal of 241Am from aqueous nitrate solutions by liquid surfactant membrane containing 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester as ion carrier.	2010 Jun	20488505
Evaluation of a new oil adjuvant for use in peptide-based cancer vaccination.	2010 Oct	20678155
Development and evaluation of emulsions from Carapa guianensis (Andiroba) oil.	2010 Sep	20824515

Sample Use Guides

In Vitro Use Guide

Under the optimal conditions in the fed-batch culture with 5 g/l Sorbitan monooleate (Span 80), the cell mass and the concentration, content, and productivity of retinal were 24.7 g/l, 600 mg/l, 24.3mg/g-cells, and 18 mg l(-1)h(-1) after 33 h, respectively.

Name

Type

Language

SORBITAN MONOOLEATE

Official Name

English

sorbitan oleate [INN]

Common Name

English

INS NO.494

Code

English

SORBITAN, MONO-9-OCTADECENOATE

Common Name

English

SORBITAN MONO-OLETAE

Common Name

English

SORBITAN MONOOLEATE [FCC]

Common Name

English

SORBITAN MONOOLEATE [VANDF]

Common Name

English

ARLACEL 80

Brand Name

English

SORBITAN, MONO-(9Z)-9-OCTADECENOATE

Common Name

English

NSC-406239

Code

English

SORBITAN OLEATE

Official Name

English

SPAN 80

Brand Name

English

SORBITAN MONOOLEATE [II]

Common Name

English

SORBITAN MONOOLEATE [USAN]

Common Name

English

D-GLUCITOL, 1,4-ANHYDRO-, 6-(9-OCTADECENOATE)

Common Name

English

SORBITAN ESTERS SORBITAN OLEATE [MI]

Common Name

English

SORBITAN OLEATE [EP MONOGRAPH]

Common Name

English

INS-494

Code

English

ANHYDROSORBITOL MONOOLEATE

Common Name

English

E-494

Code

English

SORBITAN OLEATE [MART.]

Common Name

English

Sorbitan mono-oleate [WHO-DD]

Common Name

English

1,4-ANHYDRO-D-GLUCITOL, 6-(9-OCTADECENOATE

Common Name

English

SORBITAN OLEATE [INCI]

Common Name

English

SORBITAN MONOOLEATE [HSDB]

Common Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-494

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

CFR

21 CFR 173.75

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

JECFA EVALUATION

INS-494

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

NCI_THESAURUS

C83486

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

Code System Code Type Description

NSC

406239

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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EVMPD

SUB23477

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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SMS_ID

100000088792

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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RXCUI

1363056

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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RxNorm

ECHA (EC/EINECS)

215-665-4

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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MERCK INDEX

m10120

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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Merck Index

CAS

1338-43-8

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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MESH

C018665

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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ChEMBL

CHEMBL2107274

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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INN

1875

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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FDA UNII

06XEA2VD56

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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EPA CompTox

DTXSID6027397

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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WIKIPEDIA

Sorbitan monooleate

Created by admin on Sat Dec 16 16:58:16 GMT 2023 , Edited by admin on Sat Dec 16 16:58:16 GMT 2023

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EVMPD

SUB10598MIG

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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HSDB

5822

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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PUBCHEM

9920342

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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DAILYMED

06XEA2VD56

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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NCI_THESAURUS

C75654

Created by admin on Sat Dec 16 16:58:15 GMT 2023 , Edited by admin on Sat Dec 16 16:58:15 GMT 2023

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ACTIVE MOIETY


					06XEA2VD56

SORBITAN MONOOLEATE