U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C24H16N6
Molecular Weight 388.424
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RIDINILAZOLE

SMILES

N1C2=CC(=CC=C2N=C1C3=CC=NC=C3)C4=CC=C5N=C(NC5=C4)C6=CC=NC=C6

InChI

InChIKey=UHQFBTAJFNVZIV-UHFFFAOYSA-N
InChI=1S/C24H16N6/c1-3-19-21(29-23(27-19)15-5-9-25-10-6-15)13-17(1)18-2-4-20-22(14-18)30-24(28-20)16-7-11-26-12-8-16/h1-14H,(H,27,29)(H,28,30)

HIDE SMILES / InChI
Ridinilazole (SMT19969) is a compound that was developed as a treatment for Clostridium difficile infection, which is a spore-forming bacterial infection and the leading cause of infectious healthcare-associated diarrhea. Ridinilazole has a highly targeted spectrum of activity and can spare the normal gut microbiota. A phase I clinical trial demonstrated that oral ridinilazole is well tolerated. A phase II study showed the potential of ridinilazole in treatment of initial Clostridium difficile infection and showed that this drug can reduce recurrence of the disease. In 2019, recruitment for phase III trials was still ongoing.

Approval Year

Patents

Patents

Name Type Language
RIDINILAZOLE
INN   WHO-DD  
INN   USAN  
Official Name English
ridinilazole [INN]
Common Name English
5,5'-BI-1H-BENZIMIDAZOLE, 2,2'-DI-4-PYRIDINYL-
Systematic Name English
RIDINILAZOLE [USAN]
Common Name English
SMT-19969
Code English
Ridinilazole [WHO-DD]
Common Name English
SMT19969
Code English
2,2'-DIPYRIDIN-4-YL-1H,1'H-5,5'-BIBENZIMIDAZOLE
Systematic Name English
2,2'-BIS(4-PYRIDYL)-3H,3'H-5,5'-BIBENZIMIDAZOLE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C258
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
Code System Code Type Description
WIKIPEDIA
Ridinilazole
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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NCI_THESAURUS
C152212
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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INN
10075
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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USAN
HI-232
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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DRUG BANK
DB15308
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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PUBCHEM
16659285
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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CAS
308362-25-6
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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FDA UNII
06DX01190R
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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SMS_ID
300000000301
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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EPA CompTox
DTXSID101028337
Created by admin on Sat Dec 16 09:36:27 GMT 2023 , Edited by admin on Sat Dec 16 09:36:27 GMT 2023
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