Details
Stereochemistry | RACEMIC |
Molecular Formula | 2C8H15O2.Co |
Molecular Weight | 345.3402 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Co++].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O
InChI
InChIKey=QAEKNCDIHIGLFI-UHFFFAOYSA-L
InChI=1S/2C8H16O2.Co/c2*1-3-5-6-7(4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+2/p-2
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/26210821Curator's Comment: description was created based on several sources, including:
https://www.nicnas.gov.au/chemical-information/imap-assessments/imap-group-assessment-report?assessment_id=1143 | https://www.ncbi.nlm.nih.gov/pubmed/20946461 | https://www.ncbi.nlm.nih.gov/pubmed/16637815
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26210821
Curator's Comment: description was created based on several sources, including:
https://www.nicnas.gov.au/chemical-information/imap-assessments/imap-group-assessment-report?assessment_id=1143 | https://www.ncbi.nlm.nih.gov/pubmed/20946461 | https://www.ncbi.nlm.nih.gov/pubmed/16637815
Cobaltous 2-ethylhexanoate (cobalt octoate) is an accelerator in the polyester resins. There have been several reports of allergic contact dermatitis resulting from cobaltous 2-ethylhexanoate. It was demonstrated, that cobalt octoate induced DNA strand breakage in vitro (in human cells), but the damage appeared to be explained by oxidative damage resulting from reactive oxygen species, probably caused by the cobalt cation.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26210821 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
Occupational allergic contact dermatitis to cobalt octoate included as an accelerator in a polyester resin. | 2006 May |
|
Occupational cobalt-allergic contact dermatitis resulting from polyester resin. | 2010 Nov |
|
New investigations into the genotoxicity of cobalt compounds and their impact on overall assessment of genotoxic risk. | 2015 Oct |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26210821
Following a 4 h exposure of A549 cells to both AAF and Gamble's solution extracts of cobalt octoate, DCFH was oxidised resulting in a strong increase of DCF fluorescence (up to 949% in AAF and 725% in Gamble's solution). Metabolic activity and DNA content were reduced after incubation with high concentrations of cobalt octoate (400 and 800 ug/mL, particulate fractions). Here, ROS formation was already observed at non-cytotoxic concentrations (<400 ug/mL) of cobalt octanoate.
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205-250-6
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DTXSID0027064
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SUBSTANCE RECORD