Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H16F3NO |
| Molecular Weight | 295.2995 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC[C@@H](OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2
InChI
InChIKey=WIQRCHMSJFFONW-OAHLLOKOSA-N
InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2/t15-/m1/s1
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15886723 | https://www.ncbi.nlm.nih.gov/pubmed/10208643 | https://www.ncbi.nlm.nih.gov/pubmed/8512621
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15886723 | https://www.ncbi.nlm.nih.gov/pubmed/10208643 | https://www.ncbi.nlm.nih.gov/pubmed/8512621
(R)-Norfluoxetine is a pharmacologically active metabolite of Fluoxetine that is a selective serotonin reuptake inhibitor. (R)-Norfluoxetine was being investigated by Eli Lilly and Company for treatment pain and drug abuse, but future development was discontinued.
CNS Activity
Originator
Approval Year
Sample Use Guides
Rat cortical membranes equivalent to 50 mkg of protein were incubated at 37°C for 30 minutes in 2 ml of reaction medium containing the (R)-Norfluoxetine (1-1000nM), 0.1 nM [3Hlparoxetine, 50 mmol/L Tris-HG, pH 7.4, 150 mmol/L NaG, and 5 mmol/L KCl. Fluoxetine at 1 mkM/kg was used to determine nonspecific binding
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130194-43-3
Created by
admin on Sat Dec 16 09:49:31 GMT 2023 , Edited by admin on Sat Dec 16 09:49:31 GMT 2023
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9797657
Created by
admin on Sat Dec 16 09:49:31 GMT 2023 , Edited by admin on Sat Dec 16 09:49:31 GMT 2023
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05UQ1299DN
Created by
admin on Sat Dec 16 09:49:31 GMT 2023 , Edited by admin on Sat Dec 16 09:49:31 GMT 2023
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SUBSTANCE RECORD
