Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Al.2Na.6O.Si.H2O |
Molecular Weight | 242.0398 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[O--].[O--].[O--].[O--].[O--].[O--].[Na+].[Na+].[Al+3].[Al+3].[Si+4]
InChI
InChIKey=JYIMWRSJCRRYNK-UHFFFAOYSA-N
InChI=1S/2Al.2Na.H2O.6O.Si/h;;;;1H2;;;;;;;/q2*+3;2*+1;;6*-2;+4
Aluminium silicate is a compound made from aluminum, oxygen and silicate that can take the form of a mineral as well as combine with water to make a clay. Aluminum silicate comes in three mineral forms: andalusite, kyanite and sillimanite, all of which have the chemical formula Al2SiO5 but have distinct crystal structures. When magnesium aluminum silicate is hydrated it becomes a clay known as kaolin, which is used for treating ailments such as diarrhea and to combat diaper rash as well as rashes from poison oak and poison ivy. When combined with magnesium and hydrated, the result is a clay mixture that sees common use in antacids as well as a thickener for cosmetics and other beauty products. It also appears as an inactive ingredient for deodorants. The kyanite form of aluminium silicate is used to create mullite for industrial use, and this compound is used by the ceramics industry as a refractory, as well as to manufacture electrical insulating materials and heating elements. Aluminium silicate (aluminum oxide silicate), under the brand name Adsorbin among others, is used as antidiarrheal agent and intestinal adsorbent. Kaolin (hydrated aluminum silicate) has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac rashes. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Inactive ingredient | PLENDIL 451 Approved UsePlendil is used in the treatment of high blood pressure; raynaud's syndrome; angina pectoris prophylaxis and belongs to the drug class calcium channel blocking agents. Risk cannot be ruled out during pregnancy. Launch Date1991 |
PubMed
Title | Date | PubMed |
---|---|---|
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite. | 2003 |
Patents
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JECFA EVALUATION |
INS-554
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DSLD |
3144 (Number of products:3)
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CODEX ALIMENTARIUS (GSFA) |
INS-554
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CFR |
21 CFR 582.2727
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FDA ORPHAN DRUG |
192704
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058TS43PSM
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Sodium aluminium silicate
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1344-00-9
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SUB12837MIG
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215-684-8
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DTXSID7026021
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5027
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058TS43PSM
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72941443
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100000087567
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SUBSTANCE RECORD