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Details

Stereochemistry ACHIRAL
Molecular Formula 2Al.2Na.6O.Si.H2O
Molecular Weight 242.0398
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM ALUMINOSILICATE

SMILES

O.[O--].[O--].[O--].[O--].[O--].[O--].[Na+].[Na+].[Al+3].[Al+3].[Si+4]

InChI

InChIKey=JYIMWRSJCRRYNK-UHFFFAOYSA-N
InChI=1S/2Al.2Na.H2O.6O.Si/h;;;;1H2;;;;;;;/q2*+3;2*+1;;6*-2;+4

HIDE SMILES / InChI
Aluminium silicate is a compound made from aluminum, oxygen and silicate that can take the form of a mineral as well as combine with water to make a clay. Aluminum silicate comes in three mineral forms: andalusite, kyanite and sillimanite, all of which have the chemical formula Al2SiO5 but have distinct crystal structures. When magnesium aluminum silicate is hydrated it becomes a clay known as kaolin, which is used for treating ailments such as diarrhea and to combat diaper rash as well as rashes from poison oak and poison ivy. When combined with magnesium and hydrated, the result is a clay mixture that sees common use in antacids as well as a thickener for cosmetics and other beauty products. It also appears as an inactive ingredient for deodorants. The kyanite form of aluminium silicate is used to create mullite for industrial use, and this compound is used by the ceramics industry as a refractory, as well as to manufacture electrical insulating materials and heating elements. Aluminium silicate (aluminum oxide silicate), under the brand name Adsorbin among others, is used as antidiarrheal agent and intestinal adsorbent. Kaolin (hydrated aluminum silicate) has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac rashes. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
PLENDIL 451

Approved Use

Plendil is used in the treatment of high blood pressure; raynaud's syndrome; angina pectoris prophylaxis and belongs to the drug class calcium channel blocking agents. Risk cannot be ruled out during pregnancy.

Launch Date

1991
PubMed

PubMed

TitleDatePubMed
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
2003
Patents

Sample Use Guides

Diarrhea: 12 years of age and older: 26.2 g after each loose stool every 6 hours until firm stool; do not exceed more than 262 g per 24 hours; do not use longer than 2 days.
Route of Administration: Oral
Name Type Language
SODIUM ALUMINIUM SILICATE
Preferred Name English
SODIUM ALUMINOSILICATE
FCC   HSDB  
Common Name English
SODIUM ALUMINUM SILICATE
Systematic Name English
ALUMINIUM SODIUM SILICATE [MART.]
Common Name English
SODIUM ALUMINOSILICATE [FCC]
Common Name English
SODIUM ALUMINOSILICATE [HSDB]
Common Name English
SODIUM-ALUMINOSILICATE
Common Name English
INS-554
Code English
E-554
Code English
ALUSIL SD533
Brand Name English
ZEOLEX 330
Brand Name English
SODIUM SILICOALUMINATE [INCI]
Common Name English
VALFOR ZEOLITE NA-A
Brand Name English
INS NO.554
Code English
SODIUM SILICOALUMINATE
INCI  
INCI  
Official Name English
E554
Common Name English
Aluminium sodium silicate [WHO-DD]
Common Name English
ALUSIL ET
Brand Name English
SODIUM-SILICOALUMINATE
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-554
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
DSLD 3144 (Number of products:3)
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-554
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
CFR 21 CFR 582.2727
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
FDA ORPHAN DRUG 192704
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
Code System Code Type Description
FDA UNII
058TS43PSM
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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WIKIPEDIA
Sodium aluminium silicate
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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CAS
1344-00-9
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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EVMPD
SUB12837MIG
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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ECHA (EC/EINECS)
215-684-8
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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EPA CompTox
DTXSID7026021
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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HSDB
5027
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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DAILYMED
058TS43PSM
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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PUBCHEM
72941443
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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SMS_ID
100000087567
Created by admin on Fri Dec 15 16:07:53 GMT 2023 , Edited by admin on Fri Dec 15 16:07:53 GMT 2023
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